Pregled po projektu: Dizajn, sinteza i evaluacija novih protuotrova kod trovanja živčanim bojnim otrovima i pesticidima (CHOLINESTERASE) (MB: IP-2013-11-4307)
Pronađeno 91 radova
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1.Marić, Petra; Ahel, Marijan; Maraković, Nikola; Lončar, Jovica; Mihaljević, Ivan; Smital, TvrtkoSelective interaction of microcystin congeners with zebrafish (Danio rerio) Oatp1d1 transporter // Chemosphere, 283 (2021), 131155, 12 doi:10.1016/j.chemosphere.2021.131155 (međunarodna recenzija, članak, znanstveni)
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2.Maček Hrvat, Nikolina; Žunec, Suzana; Kovarik, ZrinkaPralidoxime analogues and acetylcholinesterase mutants in counteracting tabun poisoning // Arhiv za higijenu rada i toksikologiju 72 (Suppl.1) / Lyons, Daniel M ; Brčić Karačonji, Irena ; Kopjar, Nevenka ; Herman, Makso (ur.).
Zagreb, 2021. str. 47-47 (poster, domaća recenzija, sažetak, znanstveni) -
3.Maček Hrvat, Nikolina; Kovarik, ZrinkaCounteracting poisoning with chemical warfare nerve agents // Arhiv za higijenu rada i toksikologiju, 71 (2020), 4; 266-284 doi:10.2478/aiht-2020-71-3459 (međunarodna recenzija, pregledni rad, znanstveni)
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4.Knežević, Anamarija; Novak, Jurica; Bosak, Anita; Vinković, MarijanaStructural isomers of saligenin-based β2-agonists: synthesis and insight into the reaction mechanism // Organic & biomolecular chemistry, 18 (2020), 47; 9675-9688 doi:10.1039/d0ob02095h (međunarodna recenzija, članak, znanstveni)
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5.Maraković, Nikola; Knežević, Anamarija; Rončević, Igor; Brazzolotto, Xavier; Kovarik, Zrinka; Šinko, GoranEnantioseparation, in vitro testing, and structural characterization of triple-binding reactivators of organophosphate-inhibited cholinesterases // Biochemical Journal, 477 (2020), 2771-2790 doi:10.1042/bcj20200192 (međunarodna recenzija, članak, znanstveni)
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6.Zorbaz, Tamara; Kovarik, ZrinkaNeuropharmacology: Oxime antidotes for organophosphate pesticide and nerve agent poisoning // Periodicum biologorum, 121-122 (2020), 1-2; 35-54 (međunarodna recenzija, pregledni rad, znanstveni)
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7.Kovarik, Zrinka; Maček Hrvat, NikolinaEfficient detoxification of nerve agents by oxime-assisted reactivation of acetylcholinesterase mutants // Neuropharmacology, 171 (2020), 1-7 doi:10.1016/j.neuropharm.2020.108111 (međunarodna recenzija, pregledni rad, znanstveni)
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8.Zorbaz, Tamara; Mišetić, Petra; Probst, Nicolas; Žunec, Suzana; Zandona, Antonio; Mendaš, Gordana; Micek, Vedran; Maček Hrvat, Nikolina; Katalinić, Maja; Braïki, Anissa et al.Pharmacokinetic evaluation of brain penetrating morpholine-3-hydroxy-2-pyridine oxime as an antidote for nerve agent poisoning // ACS Chemical Neuroscience, 11 (2020), 7; 1072-1084 doi:10.1021/acschemneuro.0c00032 (međunarodna recenzija, članak, znanstveni)
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9.Bosak, Anita; Bavec, Aljoša; Konte, Tilen; Šinko, Goran; Kovarik, Zrinka; Goličnik, MarkoInteractions of Paraoxonase-1 with Pharmacologically Relevant Carbamates // Molecules, 25 (2020), 1; 1-15 doi:10.3390/molecules25010211 (međunarodna recenzija, članak, znanstveni)
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10.Kovarik, Zrinka; Maček Hrvat, Nikolina; Žunec, Suzana; Katalinić, MajaDetoxification of tabun-exposed mice by an acetylcholinesterase mutant assisted with a novel pyridinium aldoxime // BIologia Serbica, 41 (2019), 2; 4-8 doi:10.5281/zenodo.3532038 (međunarodna recenzija, članak, znanstveni)
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11.Zorbaz, Tamara; Mišetić, Petra; Žunec, Suzana; Mendaš, Gordana; Micek, Vedran; Pavošević, Kristian; Gabelica Marković, Vesna; Jean, Ludovic; Renard, Pierre-Yves; Kovarik, ZrinkaPharmacodynamic and pharmacokinetic evaluation of morpholine-3-hydroxy-2-pyridine oxime, centrally active antidote for nerve agent poisoning // Book of Abstracts of the Congress of the Croatian Society of Biochemistry and Molecular Biology ˝Crossroads in Life Sciences˝, HDBMB2019, Lovran, Hrvatska, 2019
Lovran, Hrvatska, 2019. str. 135-135 (poster, domaća recenzija, sažetak, znanstveni) -
12.Šinko, GoranAssessment of scoring functions and in silico parameters for AChE-ligand interactions as a tool for predicting inhibition potency // Chemico-biological interactions, 308 (2019), 216-223 doi:10.1016/j.cbi.2019.05.047 (međunarodna recenzija, članak, znanstveni)
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13.Kovarik, Zrinka; Maček Hrvat, Nikolina; Kalisiak, Jarosław; Katalinić, Maja; Sit, Rakesh K.; Zorbaz, Tamara; Radić, Zoran; Fokin, Valery V.; Sharpless, K. Barry; Taylor, PalmerCounteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase // Toxicology and Applied Pharmacology, 372 (2019), 40-46 doi:10.1016/j.taap.2019.04.007 (međunarodna recenzija, članak, znanstveni)
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14.Kovarik, Zrinka; Kalisiak, Jarosław; Maček Hrvat, Nikolina; Katalinić, Maja; Zorbaz, Tamara; Žunec, Suzana; Green, Carol; Radić, Zoran; Fokin, Valery V.; Sharpless, Barry K.; Taylor, PalmerReversal of tabun toxicity enabled by a triazole-annulated oxime library - reactivators of acetylcholinesterase // Chemistry - A European Journal, 25 (2019), 16; 4100-4114 doi:10.1002/chem.201805051 (međunarodna recenzija, članak, znanstveni)
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15.Bosak, Anita; Vinković, Vladimir; Primožič, Ines; Kovarik, ZrinkaCarbamates of bronchodilators and Cinchona based alkaloids as selective BChE inhibitors // Arhiv za higijenu rada i toksikologiju, Vol.69, No. 3, 2018
Zagreb, Hrvatska, 2018. str. A42-42 (predavanje, domaća recenzija, sažetak, znanstveni) -
16.Kovarik, ZrinkaIntroduction to the workshop on “Reactivators and Medical Countermeasures against Nerve Agents and Pesticides” // Arhiv za higijenu rada i toksikologiju Vol.69(3)
Zagreb, Hrvatska, 2018. str. A33-A33 (predavanje, domaća recenzija, sažetak, znanstveni) -
17.Kerep, RobertInhibicija kolinesteraza karbamatom albuterola, 2018., diplomski rad, diplomski, Prirodoslovno-matematički fakultet, Zagreb
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18.Maraković, Nikola; Vinković, Vladimir; Kovarik, Zrinka; Šinko, GoranDesign, synthesis, and reactivation efficiency of chiral N-substituted 2-hydroxyiminoacetamides // Workshop on “Reactivators and Medical Countermeasures against Nerve Agents and Pesticides” : Meeting abstract, u Arhiv za higijenu rada i toksikologiju Vol.69(3)
Zagreb, Hrvatska, 2018. str. A37-A37 (predavanje, domaća recenzija, sažetak, znanstveni) -
19.Maček Hrvat, Nikolina; Sit, Rakesh K.; Kovarik, Zrinka; Žunec, Suzana; Green, Carol; Fokin, Valery V; Sharpless, K. Barry; Radić, Zoran; Taylor, PalmerRS194B pharmacokinetics and antidotal potential in mice exposed to VX and sarin // Arhiv za higijenu rada i toksikologiju Vol.69(3)
Zagreb, 2018. str. A23-A23 (predavanje, domaća recenzija, sažetak, znanstveni) -
20.Zorbaz, Tamara; Mišetić, Petra; Maraković, Nikola; Zandona, Antonio; Katalinić, Maja; Maček Hrvat, Nikolina; Braiki, Anissa; Gabelica Marković, Vesna; Jean, Ludovic; Renard, Pierre-Yves; Kovarik, ZrinkaPotent lipophilic 3-hydroxy-2-pyridinium aldoxime reactivators of phosphorylated cholinesterases // Arhiv za higijenu rada i toksikologiju Vol. 69(3)
Zagreb, Hrvatska, 2018. str. A39-A39 (predavanje, domaća recenzija, sažetak, znanstveni) -
21.Zorbaz, TamaraNovi pristup analizi oksima dizajniranih za zaštitu središnjega živčanoga sustava pri trovanju organofosfornim spojevima, 2018., doktorska disertacija, Prirodoslovno-matematički fakultet, Zagreb, Hrvatska
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22.Maček Hrvat, Nikolina; Green, Carol; Žunec, Suzana; Radić, Zoran; Taylor, Palmer; Kovarik, ZrinkaPost-exposure treatment with the oxime RS194B rapidly reactivates brain acetylcholinesterase activity in mice exposed to sarin and VX // Book of Abstracts of the 10th Congress of Toxicology in Developing Countries and 12th Congress of the Serbian Society of Toxicology
Beograd, Srbija, 2018. str. 154-155 (poster, međunarodna recenzija, sažetak, znanstveni) -
23.Kovarik, ZrinkaPseudo-catalytic nerve agents scavenging by acetylcholinesterase assisted with aldoximes // 33. Latin-American Congreee of Chemistry (33-CLAQ) and X Congress of Chemical Sciences, Technology and Inovation (QUIMICUBA 2018)
Havana, 2018. str. 92-92 (pozvano predavanje, međunarodna recenzija, sažetak, znanstveni) -
24.Malinak, Davis; Zorbaz, Tamara; Skarka, Adam; Hrabinova, Martina; Marakovic, Nikola; Janockova, Jana; Soukup, Ondrej; Misik, Jan; Jun, Daniel; Kuca, Kamil et al.Oximes with ortho-positioned chlorine moiety exhibit improved physical-chemical properties, efficient reactivation of inhibited human acetylcholinesterase and reduced in vivo toxicity // Programme and Abstract Book, Military Medical Science Letters - Special Issue on the occasion of the 13th International Meeting on Cholinesterases and the 7th International Conference on Paraoxonases, Hradec Králové, Republika Češka, 2018 / Korábečný, Jan ; Soukup, Ondrej (ur.).
Hradec Kralove: University of Defence, Faculty of Military Health Sciences, Czech Republic, 2018. str. 38-38 (pozvano predavanje, međunarodna recenzija, sažetak, znanstveni) -
25.Kovarik, Zrinka; Zorbaz, Tamara; Musilek, KamilReactivation of inhibited acetylcholinesterase with newly synthesized chlorinated pyridinium aldoximes // FEBS Open Bio, 43rd FEBS Congress, Prag, Češka Republika
Prag, Češka Republika, 2018. str. 96-96 (predavanje, međunarodna recenzija, sažetak, ostalo)
