Naslov
Anisakis spp. genomic epidemiology - scratching the surface of an emerging zoonosis

Autori
Mladineo, Ivona ; Trumbić, Željka ; Bušelić Garber, Ivana ; Hrabar, Jerko ; Vrbatović, Anamarija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Molecular Helminthology: An Integrated Approach Abstract Book / LoVerde, Phillip T. ; Lustigman, Sara - : Elsevier, 2019, 1-1

Skup
Molecular Helminthology: An Integrated Approach

Mjesto i datum
San Antonio (TX), Sjedinjene Američke Države, 07.04.2019. - 10.04.2019

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Anisakis, fish, cetacean, human

Sažetak
Global migration and trade of the foodstuff, climate change, novel trends in human eating habits characterised by an elevated demand for raw food, are considered as major reasons why reports of food borne infections, especially zoonotic parasitosis, have increased in the last decade. Consequently, health authorities and fishing industry have increasingly become aware of the significance of nematode genus Anisakis, which affects human health and the commercial value of fish products. Adriatic fish, marketed fresh, frozen, salted or marinated and exported to EC, are frequently rejected on the border because of Anisakis infection. Although considered one of the most significant emerging food-borne zoonosis, anisakiasis in many Mediterranean countries is still misdiagnosed or underestimated. During a four-year research within the project AnGEl (Anisakis spp: Genomic Epidemiology) funded by the Croatian Science Foundation, we have assessed Anisakis using a multidisciplinary approach, studying the fish as paratenic, cetaceans as the final and men as accidental host. The project resulted in new knowledge on: i) molecular geo-distribution of Anisakis spp. and its hybrids in the Adriatic Sea fish inferred by a newly developed genome-derived small sequence repeats (SSR) tool ; ii) the histopathological effect of the nematode in the digestive tract of the paratenic, final and the model accidental host inferred by IHC and TEM ; iii) the nematode transciptomic signature during migration through the model host using RNAseq and microRNA quantification ; iv) traits of the larval multixenobiotic resistance mechanisms that will help to design more effective therapy ; v) anti-Anisakis IgE seroprevalence in human population professionally related to the fish processing industry. The most important results will be presented, aiming to trigger better conscience and take home message about this emerging and highly under- and missdiagnosed zoonosis.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Veterinarska medicina, Biotehnologija

POVEZANOST RADA