Naslov
Glia in Amyotrophic Lateral Sclerosis and Spinal Cord Injury: Common Therapeutic Targets

Autori
Ban, Jelena ; Mladinic, Miranda ; Sámano, Cynthia ; Munitic, Ivana

Izvornik
Croatian medical journal (0353-9504) 60 (2019), 2; 109-120

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
amyotrophic lateral sclerosis ; spinal cord injury ; astrocytes ; microglia ; oligodendrocytes

Sažetak
The toolkit for repairing damaged neurons in amyotrophic lateral sclerosis (ALS) and spinal cord injury (SCI) is extremely limited. Here, we reviewed the in vitro and in vivo studies and clinical trials on nonneuronal cells in the neurodegenerative processes common to both these conditions. Special focus was directed to microglia and astrocytes, because their activation and proliferation, also known as neuroinflammation, is a key driver of neurodegeneration. Neuroinflammation is a multifaceted process that evolves during the disease course, and can be either beneficial or toxic to neurons. Given the fundamental regulatory functions of glia, pathogenic mechanisms in neuroinflammation represent promising therapeutic targets. We also discussed neuroprotective, immunosuppressive, and stem- cell based approaches applicable to both ALS and SCI.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA