Naslov
Application of CellDesigner program for nutrition planning and food safety control

Autori
Marić, Lucija ; Malešić, Elena ; Šanko, Katarina ; Jurina, Tamara ; Valinger, Davor ; Gajdoš Kljusurić, Jasenka ; Benković, Maja ; Jurinjak Tušek, Ana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Sixth International Conference Sustainable Postharvest and Food Technologies INOPTEP 2019 Book of Abstracts / Babić, Mirko ; Pavkov, Ivan ; Radojčin, Milivoj - Novi Sad : National Society of Processing and Energy in Agriculture, Novi Sad, Serbia, 2019, 109-109

ISBN
978-86-7520-458-9

Skup
6th International Conference Sustainable postharvest and food technologies (INOPTEP 2019) ; 31st National Conference Prosessing and Energy in Agriculture (PTEP 2019)

Mjesto i datum
Kladovo, Srbija, 07.04.2019. - 12.04.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
CellDesigner ; mathematical modelling ; nutrition planning ; food safety

Sažetak
Despite of their high potential, computational modelling and simulation techniques are still marginally used in nutritional science. Taking into account that practically all cellular processes can be affected by diet and lifestyle and that nutrients and non-nutrient components of food alter the metabolic functions of the cell in complex ways, the usage of computational tool for understanding the role of nutritional compounds on the cell is mandatory. Over the years numerous researchers demonstrated that public heath nutritional recommendations are not suitable for precise nutrition planning and that personalized nutrition should be adopted. Personalized nutrition designs the nutrition plan based on specific biological requirements of the individual taking into account its health status. To explain the interconnections between nutrition and health status multiple biological process occurring in various tissues should be included, which is impossible without the use of computational modelling tools. In this work the application of CellDesigner 4.0 (Systems Biology Institute (SBI), Tokyo, Japan) for nutrition planning and food safety control was tested through three models: (i) model of the glycolysis metabolism, (ii) folate-mediated 1-carbon metabolism and (iii) arsenic metabolism in the liver. Each model was simulated with different initial nutrient concentrations and with different enzymes activities. After model design and simulations in CellDesigner, it can be concluded that the use of computational tools allows fast and reproducible analysis of different input concentrations and the effect of different enzyme activity on specific metabolic process in human organisms. Application of computational modelling for nutrient based pathway ensures detail insight in metabolic process and simple control of the metabolic reaction influenced by nutrient intake. It also presents the changes based on the cell load, giving an insight to what is happening and why in a situations where a certain nutrient is dominant. Computational approach also simplifies prediction of potential hazards in foods.

Izvorni jezik
Engleski

Znanstvena područja
Prehrambena tehnologija, Nutricionizam, Interdisciplinarne biotehničke znanosti

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