Naslov
Prediction of radioactive iodine remnant ablation failure in patients with differentiated thyroid cancer: A cohort study of 740 patients.

Autori
Prpić, Marin ; Kust, Davor ; Kruljac, Ivan ; Kirigin, Lora S ; Jukić, Tomislav ; Dabelić, Nina ; Bolanča, Ante ; Kusić, Zvonko

Izvornik
Head and neck-journal for the sciences and specialties of the head and neck (1043-3074) 39 (2017), 1; 109-115

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
I-131 ; predictive factors ; radioactive iodine therapy ; thyroglobulin ; thyroid ablation failure ; thyroid cancer

Sažetak
BACKGROUND: The purpose of this study was to detect parameters that could serve as predictors of radioactive iodine (I-131) ablation failure in patients with low-risk and intermediate-risk differentiated thyroid carcinoma (DTC). METHODS: Our cohort study included 740 patients with DTC who received postoperative I-131 remnant ablation. Anthropometric, biochemical, and pathohistological parameters were analyzed and correlated with ablation outcome using multivariable logistic regression models. RESULTS: Treatment failure rates were higher in patients <53 years, with N1a classification, and lymph node capsular invasion. In patients with N1a disease, thyroglobulin (Tg) > 2.4 ng/mL predicted treatment failure with 93.8% sensitivity and 52.5% specificity, and in patients with N1b disease, Tg > 14.9 ng/mL with 77.8% sensitivity and 92.9% specificity. I-131 activity was not associated with treatment outcome. CONCLUSION: Patients < 53 years old, with higher Tg levels, N1a classification, and lymph node capsular invasion have a higher risk of ablation failure. Stimulated Tg is an excellent predictor of treatment failure in patients with N1 disease.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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