Naslov
Neuron to glia signaling triggers myelin membrane exocytosis from endosomal storage sites

Autori
Trajkovic, Katarina ; Dhaunchak, Ajit Singh ; Goncalves, José T. ; Wenzel, Dirk ; Schneider, Anja ; Bunt, Gertrude ; Nave, Klaus-Armin ; Simons, Mikael

Izvornik
The Journal of Cell Biology (0021-9525) 172 (2006), 6; 937-948

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
neuron, glia, exocytosis, endocytosis, lysosomes

Sažetak
During vertebrate brain development, axons are enwrapped by myelin, an insulating membrane produced by oligodendrocytes. Neuron-derived signaling molecules are temporally and spatially required to coordinate oligodendrocyte differentiation. In this study, we show that neurons regulate myelin membrane trafficking in oligodendrocytes. In the absence of neurons, the major myelin membrane protein, the proteolipid protein (PLP), is internalized and stored in late endosomes/lysosomes (LEs/Ls) by a cholesterol-dependent and clathrin-independent endocytosis pathway that requires actin and the RhoA guanosine triphosphatase. Upon maturation, the rate of endocytosis is reduced, and a cAMP- dependent neuronal signal triggers the transport of PLP from LEs/Ls to the plasma membrane. These findings reveal a fundamental and novel role of LEs/Ls in oligodendrocytes: to store and release PLP in a regulated fashion. The release of myelin membrane from LEs/Ls by neuronal signals may represent a mechanism to control myelin membrane growth.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

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