Naslov
Neuron-glia communication in the control of oligodendrocyte function and myelin biogenesis

Autori
Simons, Mikael ; Trajkovic, Katarina

Izvornik
Journal of Cell Science (0021-9533) 119 (2006), 21; 4381-4389

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
neuron, glia, signaling

Sažetak
During the development of the central nervous system the reciprocal communication between neurons and oligodendrocytes is essential for the generation of myelin, a multilamellar insulating membrane that ensheathes the axons. Neuron-derived signalling molecules regulate the proliferation, differentiation and survival of oligodendrocytes. Furthermore, neurons control the onset and timing of myelin membrane growth. In turn, signals from oligodendrocytes to neurons direct the assembly of specific subdomains in neurons at the node of Ranvier. Recent work has begun to shed light on the molecules and signaling systems used to coordinate the interaction of neurons and oligodendrocytes. For example, the neuronal signals seem to control the membrane trafficking machinery in oligodendrocytes that leads to myelination. These interconnections at multiple levels show how neurons and glia cooperate to build a complex network during development.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA