Pregled bibliografske jedinice broj: 997336
How B-6 helps B-12: The roles of B-6, B-12, and the enzymes in aminomutase-catalyzed reactions
How B-6 helps B-12: The roles of B-6, B-12, and the enzymes in aminomutase-catalyzed reactions // Journal of the American Chemical Society, 122 (2000), 41; 10208-10209 doi:10.1021/ja001651y (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 997336 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
How B-6 helps B-12: The roles of B-6, B-12, and the enzymes in aminomutase-catalyzed reactions
Autori
Wetmore, Stacey D. ; Smith, David M. ; Radom, Leo
Izvornik
Journal of the American Chemical Society (0002-7863) 122
(2000), 41;
10208-10209
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
METHYLMALONYL-COA MUTASE ; PARTIAL-PROTON-TRANSFER ; MECHANISM ; ADENOSYLCOBALAMIN ; REARRANGEMENT
Sažetak
The 1, 2-shift of an amino group appears to be a demanding task. Our calculations show that the rearrangement may be efficiently accomplished as a result of an intricate relationship between the enzyme and its cofactors. Thus, we believe that coenzyme B12 is responsible for activating the substrate by removal of a hydrogen atom. Vitamin B6 (PLP) introduces a seemingly essential double bond into the migrating group, as well as imparting the potential for the reaction intermediate to be captodatively stabilized. The enzyme itself holds all the components in place and provides an environment in which the pyridine nitrogen can be fully (or partially) protonated. This cooperative action of the enzyme and cofactors is able to mediate an otherwise difficult reaction.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
