Pregled bibliografske jedinice broj: 997316
GENE POLYMORPHISMS OF DNA METHYLTRANSFERASE 3B IN WOMEN WITH SPONTANEOUS PRETERM BIRTH
GENE POLYMORPHISMS OF DNA METHYLTRANSFERASE 3B IN WOMEN WITH SPONTANEOUS PRETERM BIRTH // Balkan Journal of Medical Genetics
Edirne, Turska, 2019. str. 50-51 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 997316 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
GENE POLYMORPHISMS OF DNA METHYLTRANSFERASE 3B IN WOMEN WITH SPONTANEOUS PRETERM BIRTH
Autori
Barišić, Anita ; Pereza, Nina ; Kolak, Maja ; Peterlin, Ana ; Tul, Nataša ; Gašparović Krpina, Milena ; Ostojić, Saša ; Peterlin, Borut
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Balkan Journal of Medical Genetics
/ - , 2019, 50-51
Skup
13th Balkan Congress of Human Genetics
Mjesto i datum
Edirne, Turska, 17.04.2019. - 20.04.2019
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
DNA methyltransferases ; Pregnancy ; Preterm birth ; Single nucleotide polymorphism
Sažetak
Aim: The aim of this study was to evaluate the potential association between spontaneous or idiopathic PTB (SPTB) and DNMT3B gene polymorphisms in Slavic women, and their contribution to clinical characteristics of women with SPTB and their new-borns (family history of PTB, maternal smoking before pregnancy, maternal age, gestational week at delivery and fetal birth weight). Patients and methods: A total of 162 women with SPTB and 162 women with term delivery were included in a case-control study. Genotyping of DNMT3B rs1569686 and DNMT3B rs2424913 single nucleotide polymorphisms was performed using polymerase chain reaction and restriction fragment length polymorphism methods. Results: DNMT3B rs1569686 and rs2424913 minor alleles (T) were significantly more frequent in women with familial PTB than non-familial PTB, and contributed to a 3.30 and 3.54 increased odds for familial PTB under dominant genetic models (95 % CI = 1.53-7.14, P = 0.003 and 95 % CI = 1.56-8.01, P = 0.002). Furthermore, the DNMT3B rs1569686 and rs2424913 T alleles were significantly more frequent in women with SPTB who smoked before pregnancy, reaching the most significant association under additive genetic models (OR = 6.86, 95 % CI = 2.25-20.86, P ˂ 0.001 and OR = 3.77, 95 % CI = 1.36-10.52, P = 0.011). Conclusion: The DNMT3B rs1569686 and rs2424913 gene polymorphisms in Slavic women might be associated with a positive family history of PTB and smoking status before pregnancy.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Ustanove:
Medicinski fakultet, Rijeka
