Naslov
Computational histology image analysis of human cerebral cortex cytoarchitectonics

Autori
Štajduhar, Andrija

Vrsta, podvrsta i kategorija rada
Ocjenski radovi, doktorska disertacija

Fakultet
Fakultet elektrotehnike i računarstva

Mjesto
Zagreb

Datum
28.03

Godina
2019

Stranica
120

Mentor
Lončarić, Sven ; Judaš, Miloš

Ključne riječi
image analysis ; computation histology ; image processing

Sažetak
The structure of the cerebral cortex is defined by organization and distribution of neurons in the tissue. Today, most investigations in brain cytoarchitectonics are not automatized and require significant involvement of the researcher, which is very time consuming and may introduce significant bias. This type of analysis may not be accurate enough or reveal enough information about the structure of the tissue. Brain tissue forms complex structures whose organization and distribution may be reliably revealed only using systematic computational approach. The goal of this dissertation is development of novel computational methods for automatic and objective analysis of histological images of human brain suitable for advanced and fast analysis of brain cytoarchitectonics and laminar structure. The methods were developed aiming for a completely data-driven approach, with as little assumptions about the data as possible. Quantitative analysis of neuronal distribution and exploration of underlying principles of varia- tion that facilitate parcellation of cortical layers resulted in novel framework and methodology for cellular-level investigations of brain tissue.

Izvorni jezik
Engleski

Znanstvena područja
Elektrotehnika, Računarstvo

POVEZANOST RADA