Naslov
DQCAR AND D6S273 POLYMORPHISM IN PATIENTS SUFFERING FROM RHEUMATOID ARTHRITIS

Autori
Grubić, Zorana ; Žunec, Renata ; Naglić-Babić, Đurđica ; Kerhin-Brkljačić, Vesna ; Ćurković, Božidar ; Kaštelan, Andrija

Izvornik
European Journal of Immunogenetics (0960-7420) 29 (2002), 2;

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kongresno priopcenje, znanstveni

Ključne riječi
DQCAR; D6S273; RA; MICROSATELLITE

Sažetak
Rheumatoid arthritis (RA) is a chronic articular inflammatory disease associated with DRB1 alleles that share a highly conserved amino acid sequence in the third hypervariable region of the DRB1 molecule. These associations are incomplete because not all patients carry the disease susceptibilty alleles and not all disease epitope positive individuals develop RA. The aim of the present study was to define the genetic contribution of the DQCAR and D6S273 loci in RA development. One hundred and fifteen patients with RA and 141 controls were employed for this study, in which DQCAR, D6S273, and DRB1 allele typing were performed. All patients had definite classical seropositive RA. Statistical analyses were performed using a Fisher's exact test. The frequencies of D6S273 alleles 132 (RR=1.3, p<0.01) and 138 alleles (RR=3.5, p<0.001) were significantly increased in RA patients compared with controls. On the other hand, 140 allele is the least frequent in RA patients as well as in controls (4.7% and 17%, respectively). No significant differences between RA and controls in terms of DQCAR allele frequencies could be found. Allele 138 was significantly higher in disease epitope negative patients in our population. In conclusion, these data suggest that D6S273 alleles are probably a useful risk marker for RA susceptibilty.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA