Pregled bibliografske jedinice broj: 99269
Cerebrospinal Fluid Level of Soluble Fas /APO- 1 in Acute Stroke Patients- Preliminary Report
Cerebrospinal Fluid Level of Soluble Fas /APO- 1 in Acute Stroke Patients- Preliminary Report // Journal of the Neurological Sciences
London, Ujedinjeno Kraljevstvo: Elsevier, 2001. str. S 248-S 249 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 99269 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Cerebrospinal Fluid Level of Soluble Fas /APO- 1 in Acute Stroke Patients- Preliminary Report
Autori
Mahovic Lakusic, Darija ; Petravic , Damir ; Zurak, Niko ; Vogrinc, Zeljka
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Journal of the Neurological Sciences
/ - : Elsevier, 2001, S 248-S 249
Skup
XVII World Congress of Neurology
Mjesto i datum
London, Ujedinjeno Kraljevstvo, 17.06.2001. - 22.06.2001
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Sažetak
Background and aim: The neuronal death in acute ischemic stroke has been attributed to necrosis. Recent cerebral ischemia studies in experimental animal models have indicated that apoptosis (programmed cell death) might contribute to neuronal death. The aim of this study was to analyse the cerebrospinal fluid (CSF) level of soluble (s)Fas/APO-1 (apoptosis suppressing protein) in acute ischemic stroke patients. Methods: The five patients (mean age 69&plusmn ; 6 years) with first acute ischemic stroke verified by clinical examination and CT scan were included in the study. Patients with history of autoimmune and malignant disease, congestive heart failure and sever infections were included. The control group consisted of four patients with other neurological disorders (cephalea, vertigo). Soluble Fas/APO-1 level in the CSF was determinated by ELISA (Chemicon) on day 3 and day 21 after disease onset. The results were presented by means &plusmn ; SD. Statistical analysis was performed by the Student T-test. The value of p<0, 05 was considered statistically significant. Results: The CSF levels of sFas/APO-1 in acute stroke patients were significantly increased on day 3 when compared with day 21 (0, 89 &plusmn ; 0, 56 U/ml vs. 0, 31 &plusmn ; 0, 14 U/ml, p=0, 03) and controls (0, 28 &plusmn ; 0, 09 U/ml, p=0, 03). The differences of sFas/APO-1 level in stroke patients on day 21and controls was not found. Conclusion: The preliminary results demonstrate changes in CSF levels of sFas/APO-1 in acute ischemic stroke, suggesting the presence of apoptosis and possible pathophysiological contribution to neuronal death.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Kliničke medicinske znanosti
