Naslov
Absolute configuration of 2, 6-dimethylheptyl sulfate and its distribution in Ascidiacea

Autori
De Rosa, Salvatore ; Milone, Alfredo ; Crispino, Antonio ; Jaklin, Andrej ; De Gulio, Alfonso

Izvornik
Journal of Natural Products (0163-3864) 60 (1997), 5; 462-463

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
polycitor adriaticus; 2.6-dimethylheptil; ascidiacea

Sažetak
2, 6-Dimethylheptyl sulfate (1) was isolated for the first time from a marine ascidian from Polycitor adriaticus Drasche (class Ascidiacea, order Aplousobramchiata, family Polycitoridae). In this work, the absolute stereochemistry at C-2 of 1 was determined by 1H-NRM analysis of its (+)- and (-)-methoxy(trifluoromethyl)phenylacetic acid (MTPA) esters (Mosher's method). The distribution of 1 was investigated among the three orders (Aplousobranchiata, Phlebobranchiata, and Stolidobranchiata) of the slass Ascidiacea. Compound 1 showed cytotoxicity (LC50=17.8 ľg/mL) in the Artemia salina bioassay and was not toxic (not toxicity at 100 ľg/mL) in a fish (Gambusia affinis) lethality assay.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA