Naslov
Human papillomaviruses and the specificity of PDZ domain targeting

Autori
Pim, David ; Bergant, Martina ; Boon, Siaw S. ; Ganti, Ketaki ; Kranjec, Christian ; Massimi, Paola ; Subbaiah, Vanitha K. ; Thomas, Miranda ; Tomaić, Vjekoslav ; Banks, Lawrence

Izvornik
The FEBS Journal (1742-464X) 279 (2012), 19; 3530-3537

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo

Ključne riječi
HPV E6, cervical cancer, PDZ

Sažetak
The human papillomavirus (HPV) E6 oncoprotein is fundamental to the ability of these viruses to induce human malignancy. A defining characteristic of the HPV E6 oncoproteins found in cancer‐causing HPV types is the presence of a PDZ binding motif at their extreme C‐terminus. Through this motif, E6 is able to interact with a large number of cellular proteins that contain PDZ domains. Many of these cellular proteins are involved in regulation of processes associated with the control of cell attachment, cell proliferation, cell polarity and cell signaling. How E6 targets multiple proteins containing the same recognition domain is still an open question. In this review, we highlight aspects of E6 function and biology that help to answer this question, and thereby provide insight into the role of these substrates during development of HPV‐induced malignancy.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA