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Pregled bibliografske jedinice broj: 991965

MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer

Gawrzak, Sylwia; Rinaldi, Lorenzo; Gregorio, Sara; Arenas, Enrique J.; Salvador, Fernando; Urosevic, Jelena; Figueras- Puig, Cristina; Rojo, Federico; del Barco Barrantes, Ivan; Cejalvo, Juan Miguel et al.
MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer // Nature cell biology, 20 (2018), 2; 211-221 doi:10.1038/s41556-017-0021-z (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 991965 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer

Autori
Gawrzak, Sylwia ; Rinaldi, Lorenzo ; Gregorio, Sara ; Arenas, Enrique J. ; Salvador, Fernando ; Urosevic, Jelena ; Figueras- Puig, Cristina ; Rojo, Federico ; del Barco Barrantes, Ivan ; Cejalvo, Juan Miguel ; Palafox, Marta ; Guiu, Marc ; Berenguer- Llergo, Antonio ; Symeonidi, Aikaterini ; Bellmunt, Anna ; Kalafatovic, Daniela ; Arnal-Estapé, Anna ; Fernández, Esther ; Müllauer, Barbara ; Groeneveld, Rianne ; Slobodnyuk, Konstantin ; Stephan-Otto Attolini, Camille ; Saura, Cristina ; Arribas, Joaquín ; Cortes, Javier ; Rovira, Ana ; Muñoz, Montse ; Lluch, Ana ; Serra, Violeta ; Albanell, Joan ; Prat, Aleix ; Nebreda, Angel R. ; Benitah, Salvador Aznar ; Gomis, Roger R.

Izvornik
Nature cell biology (1465-7392) 20 (2018), 2; 211-221

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
MSK ; breast cancer ; bone metastasis

Sažetak
For many patients with breast cancer, symptomatic bone metastases appear after years of latency. How micrometastatic lesions remain dormant and undetectable before initiating colonization is unclear. Here, we describe a mechanism involved in bone metastatic latency of oestrogen receptor- positive (ER+) breast cancer. Using an in vivo genome-wide short hairpin RNA screening, we identified the kinase MSK1 as an important regulator of metastatic dormancy in breast cancer. In patients with ER+ breast cancer, low MSK1 expression associates with early metastasis. We show that MSK1 downregulation impairs the differentiation of breast cancer cells, increasing their bone homing and growth capacities. MSK1 controls the expression of genes required for luminal cell differentiation, including the GATA3 and FOXA1 transcription factors, by modulating their promoter chromatin status. Our results indicate that MSK1 prevents metastatic progression of ER+ breast cancer, suggesting that stratifying patients with breast cancer as high or low risk for early relapse based on MSK1 expression could improve prognosis.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Profili:

Avatar Url Daniela Kalafatović (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com

Citiraj ovu publikaciju:

Gawrzak, Sylwia; Rinaldi, Lorenzo; Gregorio, Sara; Arenas, Enrique J.; Salvador, Fernando; Urosevic, Jelena; Figueras- Puig, Cristina; Rojo, Federico; del Barco Barrantes, Ivan; Cejalvo, Juan Miguel et al.
MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer // Nature cell biology, 20 (2018), 2; 211-221 doi:10.1038/s41556-017-0021-z (međunarodna recenzija, članak, znanstveni)
Gawrzak, S., Rinaldi, L., Gregorio, S., Arenas, E., Salvador, F., Urosevic, J., Figueras- Puig, C., Rojo, F., del Barco Barrantes, I. & Cejalvo, J. (2018) MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer. Nature cell biology, 20 (2), 211-221 doi:10.1038/s41556-017-0021-z.
@article{article, author = {Gawrzak, Sylwia and Rinaldi, Lorenzo and Gregorio, Sara and Arenas, Enrique J. and Salvador, Fernando and Urosevic, Jelena and Figueras- Puig, Cristina and Rojo, Federico and del Barco Barrantes, Ivan and Cejalvo, Juan Miguel and Palafox, Marta and Guiu, Marc and Berenguer- Llergo, Antonio and Symeonidi, Aikaterini and Bellmunt, Anna and Kalafatovic, Daniela and Arnal-Estap\'{e}, Anna and Fern\'{a}ndez, Esther and M\"{u}llauer, Barbara and Groeneveld, Rianne and Slobodnyuk, Konstantin and Stephan-Otto Attolini, Camille and Saura, Cristina and Arribas, Joaqu\'{\i}n and Cortes, Javier and Rovira, Ana and Mu\~{n}oz, Montse and Lluch, Ana and Serra, Violeta and Albanell, Joan and Prat, Aleix and Nebreda, Angel R. and Benitah, Salvador Aznar and Gomis, Roger R.}, year = {2018}, pages = {211-221}, DOI = {10.1038/s41556-017-0021-z}, keywords = {MSK, breast cancer, bone metastasis}, journal = {Nature cell biology}, doi = {10.1038/s41556-017-0021-z}, volume = {20}, number = {2}, issn = {1465-7392}, title = {MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer}, keyword = {MSK, breast cancer, bone metastasis} }
@article{article, author = {Gawrzak, Sylwia and Rinaldi, Lorenzo and Gregorio, Sara and Arenas, Enrique J. and Salvador, Fernando and Urosevic, Jelena and Figueras- Puig, Cristina and Rojo, Federico and del Barco Barrantes, Ivan and Cejalvo, Juan Miguel and Palafox, Marta and Guiu, Marc and Berenguer- Llergo, Antonio and Symeonidi, Aikaterini and Bellmunt, Anna and Kalafatovic, Daniela and Arnal-Estap\'{e}, Anna and Fern\'{a}ndez, Esther and M\"{u}llauer, Barbara and Groeneveld, Rianne and Slobodnyuk, Konstantin and Stephan-Otto Attolini, Camille and Saura, Cristina and Arribas, Joaqu\'{\i}n and Cortes, Javier and Rovira, Ana and Mu\~{n}oz, Montse and Lluch, Ana and Serra, Violeta and Albanell, Joan and Prat, Aleix and Nebreda, Angel R. and Benitah, Salvador Aznar and Gomis, Roger R.}, year = {2018}, pages = {211-221}, DOI = {10.1038/s41556-017-0021-z}, keywords = {MSK, breast cancer, bone metastasis}, journal = {Nature cell biology}, doi = {10.1038/s41556-017-0021-z}, volume = {20}, number = {2}, issn = {1465-7392}, title = {MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer}, keyword = {MSK, breast cancer, bone metastasis} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE
  • Nature Index

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