Naslov
Endemic (Balkan) nephropathy is aristolochic acid nephropathy.

Autori
Karanović, Sandra ; Tomić, Karla ; Dittrich, Damir ; Borovečki, Fran ; Zavadil, Jiri ; Vuković Lela, Ivana ; Karlović, Krešimir ; Knežević, Matej ; Jelaković, Bojan

Izvornik
Prilozi - Makedonska akademija na naukite i umetnostite. Oddelenie za biološki i medicinski nauki (0351-3254) 35 (2014), 1; 43-46

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
endemic nephropathy, aristolochic acid nephropathy, aristolochic acid, upper urothelial cancers, microRNA.

Sažetak
Endemic nephropathy is a syndrome that comprises two entities: chronic interstitial nephropathy and urothelial cell cancers predominantly of the upper urinary tract. The etiological agent for the disease is aristolochic acid, a compound found in the plants of Aristolochia spp. The development of urothelial cancers is characterized by the formation of aristolactam DNA adducts leading to mutations, predominantly A: T->T: A transversions. In order to comprehensively understand the gene regulation programs in upper urothelial cancers we performed integrated miRNA and mRNA expression profiling of paired tumours and unaffected urothelium samples. The obtained data will help us to understand the carcinogenesis caused by aristolochic acid and might be the source for the design of a diagnostic biomarker.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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