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Pregled bibliografske jedinice broj: 990336

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Evangelou, Evangelos; the Million Veteran Program; Warren, Helen R.; Mosen-Ansorena, David; Kolcic, Ivana; Polasek, Ozren; Pramstaller, Peter P.; Nguyen, Quang Tri; Raitakari, Olli T.; Ren, Meixia et al.
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits // Nature Genetics, 50 (2018), 10; 1412-1425 doi:10.1038/s41588-018-0205-x (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 990336 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Autori
Evangelou, Evangelos ; the Million Veteran Program ; Warren, Helen R. ; Mosen-Ansorena, David ; Kolcic, Ivana ; Polasek, Ozren ; Pramstaller, Peter P. ; Nguyen, Quang Tri ; Raitakari, Olli T. ; Ren, Meixia ; Rettig, Rainer ; Rice, Kenneth ; Ridker, Paul M. ; Ried, Janina S. ; Riese, Harriëtte ; Ripatti, Samuli ; Robino, Antonietta ; Rose, Lynda M. ; Rotter, Jerome I. ; Rudan, Igor ; Zemunik, Tatijana et al.

Izvornik
Nature Genetics (1061-4036) 50 (2018), 10; 1412-1425

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
GENOME-WIDE ASSOCIATION ; CARDIOVASCULAR-DISEASE RISK ; UK BIOBANK ; HYPERTENSION ; VARIANTS ; METAANALYSIS ; COMMON ; HEALTH ; RARE ; HYPERALDOSTERONISM

Sažetak
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

Izvorni jezik
Engleski



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Tatijana Zemunik (autor)

Avatar Url Ozren Polašek (autor)

Avatar Url Igor Rudan (autor)

Avatar Url Ivana Kolčić (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Evangelou, Evangelos; the Million Veteran Program; Warren, Helen R.; Mosen-Ansorena, David; Kolcic, Ivana; Polasek, Ozren; Pramstaller, Peter P.; Nguyen, Quang Tri; Raitakari, Olli T.; Ren, Meixia et al.
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits // Nature Genetics, 50 (2018), 10; 1412-1425 doi:10.1038/s41588-018-0205-x (međunarodna recenzija, članak, znanstveni)
Evangelou, E., the Million Veteran Program, Warren, H., Mosen-Ansorena, D., Kolcic, I., Polasek, O., Pramstaller, P., Nguyen, Q., Raitakari, O. & Ren, M. (2018) Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics, 50 (10), 1412-1425 doi:10.1038/s41588-018-0205-x.
@article{article, author = {Evangelou, Evangelos and Warren, Helen R. and Mosen-Ansorena, David and Kolcic, Ivana and Polasek, Ozren and Pramstaller, Peter P. and Nguyen, Quang Tri and Raitakari, Olli T. and Ren, Meixia and Rettig, Rainer and Rice, Kenneth and Ridker, Paul M. and Ried, Janina S. and Riese, Harri\"{e}tte and Ripatti, Samuli and Robino, Antonietta and Rose, Lynda M. and Rotter, Jerome I. and Rudan, Igor and Zemunik, Tatijana et al.}, year = {2018}, pages = {1412-1425}, DOI = {10.1038/s41588-018-0205-x}, keywords = {GENOME-WIDE ASSOCIATION, CARDIOVASCULAR-DISEASE RISK, UK BIOBANK, HYPERTENSION, VARIANTS, METAANALYSIS, COMMON, HEALTH, RARE, HYPERALDOSTERONISM}, journal = {Nature Genetics}, doi = {10.1038/s41588-018-0205-x}, volume = {50}, number = {10}, issn = {1061-4036}, title = {Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits}, keyword = {GENOME-WIDE ASSOCIATION, CARDIOVASCULAR-DISEASE RISK, UK BIOBANK, HYPERTENSION, VARIANTS, METAANALYSIS, COMMON, HEALTH, RARE, HYPERALDOSTERONISM} }
@article{article, author = {Evangelou, Evangelos and Warren, Helen R. and Mosen-Ansorena, David and Kolcic, Ivana and Polasek, Ozren and Pramstaller, Peter P. and Nguyen, Quang Tri and Raitakari, Olli T. and Ren, Meixia and Rettig, Rainer and Rice, Kenneth and Ridker, Paul M. and Ried, Janina S. and Riese, Harri\"{e}tte and Ripatti, Samuli and Robino, Antonietta and Rose, Lynda M. and Rotter, Jerome I. and Rudan, Igor and Zemunik, Tatijana et al.}, year = {2018}, pages = {1412-1425}, DOI = {10.1038/s41588-018-0205-x}, keywords = {GENOME-WIDE ASSOCIATION, CARDIOVASCULAR-DISEASE RISK, UK BIOBANK, HYPERTENSION, VARIANTS, METAANALYSIS, COMMON, HEALTH, RARE, HYPERALDOSTERONISM}, journal = {Nature Genetics}, doi = {10.1038/s41588-018-0205-x}, volume = {50}, number = {10}, issn = {1061-4036}, title = {Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits}, keyword = {GENOME-WIDE ASSOCIATION, CARDIOVASCULAR-DISEASE RISK, UK BIOBANK, HYPERTENSION, VARIANTS, METAANALYSIS, COMMON, HEALTH, RARE, HYPERALDOSTERONISM} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE
  • Nature Index

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