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Pregled bibliografske jedinice broj: 990288

Molecular defects in coagulation Factor VIII and their impact on Factor VIII function

Saenko, E. L.; Ananyeva, N.; Kouiavskaia, D.; Schwinn, H.; Josic, D.; Shima, M.; Hauser, C. A. E.; Pipe, S.
Molecular defects in coagulation Factor VIII and their impact on Factor VIII function // Vox Sanguinis, 83 (2002), 2; 89-96 doi:10.1046/j.1423-0410.2002.00183.x (međunarodna recenzija, članak, stručni)

CROSBI ID: 990288 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Molecular defects in coagulation Factor VIII and their impact on Factor VIII function

Autori
Saenko, E. L. ; Ananyeva, N. ; Kouiavskaia, D. ; Schwinn, H. ; Josic, D. ; Shima, M. ; Hauser, C. A. E. ; Pipe, S.

Izvornik
Vox Sanguinis (0042-9007) 83 (2002), 2; 89-96

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
Conformational changes ; Factor VIII ; Haemophilia A ; Mutations ; Phospholipid binding ; Surface plasmon resonance

Sažetak
Molecular defects in Factor VIII (FVIII), such as haemophilia A‐related mutations or denaturative conformational changes, may affect the stability of FVIII as well as its interactions with physiological activators, von Willebrand Factor, phospholipid, or conformationally sensitive antibodies. We summarize the contemporary assays which allow identification of impaired functional interactions of FVIII that cause a reduction or loss of its cofactor activity and/or increased immunogenicity. These assays can potentially be used for detection of molecular defects in FVIII and elucidation of the function impaired by these defects.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA

Ustanove:
Sveučilište u Rijeci - Odjel za biotehnologiju

Profili:

Avatar Url Đuro Josić (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Saenko, E. L.; Ananyeva, N.; Kouiavskaia, D.; Schwinn, H.; Josic, D.; Shima, M.; Hauser, C. A. E.; Pipe, S.
Molecular defects in coagulation Factor VIII and their impact on Factor VIII function // Vox Sanguinis, 83 (2002), 2; 89-96 doi:10.1046/j.1423-0410.2002.00183.x (međunarodna recenzija, članak, stručni)
Saenko, E., Ananyeva, N., Kouiavskaia, D., Schwinn, H., Josic, D., Shima, M., Hauser, C. & Pipe, S. (2002) Molecular defects in coagulation Factor VIII and their impact on Factor VIII function. Vox Sanguinis, 83 (2), 89-96 doi:10.1046/j.1423-0410.2002.00183.x.
@article{article, author = {Saenko, E. L. and Ananyeva, N. and Kouiavskaia, D. and Schwinn, H. and Josic, D. and Shima, M. and Hauser, C. A. E. and Pipe, S.}, year = {2002}, pages = {89-96}, DOI = {10.1046/j.1423-0410.2002.00183.x}, keywords = {Conformational changes, Factor VIII, Haemophilia A, Mutations, Phospholipid binding, Surface plasmon resonance}, journal = {Vox Sanguinis}, doi = {10.1046/j.1423-0410.2002.00183.x}, volume = {83}, number = {2}, issn = {0042-9007}, title = {Molecular defects in coagulation Factor VIII and their impact on Factor VIII function}, keyword = {Conformational changes, Factor VIII, Haemophilia A, Mutations, Phospholipid binding, Surface plasmon resonance} }
@article{article, author = {Saenko, E. L. and Ananyeva, N. and Kouiavskaia, D. and Schwinn, H. and Josic, D. and Shima, M. and Hauser, C. A. E. and Pipe, S.}, year = {2002}, pages = {89-96}, DOI = {10.1046/j.1423-0410.2002.00183.x}, keywords = {Conformational changes, Factor VIII, Haemophilia A, Mutations, Phospholipid binding, Surface plasmon resonance}, journal = {Vox Sanguinis}, doi = {10.1046/j.1423-0410.2002.00183.x}, volume = {83}, number = {2}, issn = {0042-9007}, title = {Molecular defects in coagulation Factor VIII and their impact on Factor VIII function}, keyword = {Conformational changes, Factor VIII, Haemophilia A, Mutations, Phospholipid binding, Surface plasmon resonance} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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