Naslov
Molecular analysis of HLA-DRB1, - DQA1, -DQB1, -DQCAR, haplotypic associations in Croatian patients with psoriasis

Autori
Grubić, Zorana ; Žunec, Renata ; Čečuk-Jeličić, Esma ; Kaštelan, Marija ; Gruber, Franjo ; Kaštelan, Andrija

Izvornik
Collegium Antropologicum (0350-6134) 26 (2002), 1; 61-67

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
DQCAR; polymorphism; microsatellite; HLA class II genes; psoriasis

Sažetak
The purpose of the present study was to investigate polymorphism of HLA class II haplotypic associations (HLA-DRB1, -DQA1, -DQB1) and DQCAR alleles in seventy eight Croatian patients with psoriasis. Patients were divided into two groups according to a family history of disease and age of onset: type I (positive family history and early onset) and type II (negative family history and late onset). The difference in frequency of HLA class II haplotypic associations between type I patients and controls was observed for the following combinations: HLA-DRB1*0701, -DQA1*0201, -DQB1*02 (23.6% vs 7.2% ; p<0.001), HLA-DRB1*0701, -DQA1*0201, -DQB1*0303 (8.5% vs 1.3% ; (p=0.0018) and HLA-DRB1*1601, -DQA1*0102, -DQB1*0502 (2.8% vs 9.3% ; p=0.06). The difference between type II psoriasis and controls for association: HLA-DRB1*1501, -DQA1*0102, -DQB1*0602 is not significant (20.0% vs 8.9% ; p=0.06). The significantly higher frequency of DQCAR 113bp and 119bp alleles in patients with type I psoriasis is a result of linkage disequlibrium of these alleles with both HLA-DRB1*0701 haplotypic associations. Analysis of DQCAR alleles in the HLA-DRB1*0701 haplotypic associations in patients with psoriasis vulgaris and matched controls did not reveal any difference in polymorphism of DQCAR alleles. These data suggest that HLA-DRB*0701 haplotypic combinations are associated with type I but not for type II psoriasis in the Croatian population. DQCAR polymorphism is not useful genetic marker to distinguish susceptible HLA class II haplotypic association.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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