Naslov
Towards in vitro verification of a hormone mediated feed-back mechanism of tumor growth

Autori
Vuk-Pavlović, Stanimir ; Pavelić, Krešimir

Izvornik
Periodicum biologorum (0031-5362) 84 (1982); 336-338

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
hormone mediated feed-back, tumor growth, insulin-like substance, growth hormone

Sažetak
In this paper authors review their dana which led them to formulate a hypothesis of a hormonal mechanism of the self control of tumor growth and discuss briefly the first in vitro experiments designed to confirm the hypothesis and to elaborate ways of control and modulation of this mechanism. Authors postulated that the insulin-like substance secreting tumors establish a positive feed-back, self control of their growth. According to this idea tumor secretes insulin-like substances which induces blood sugar fluctuations, which, in turn, stimulate growth hormone release in blood. Elevated levels of circulating growth hormone stimulate tumor proliferation and close the positive feed-back loop.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA