Naslov
Cyclosporine A differently affects the function of the two Main T cell subsets

Autori
Poljak, LJiljana ; Verstovšek, Srđan ; Knežević, Nikola ; Užarević, Branka ; Batinić, Drago ; Pavelić, Krešimir ; Marušić-Galešić, Suzana

Izvornik
Croatian medical journal (0353-9504) 33 (1992); 102-106

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Cyclosporine A ; T-cell subsets ; immunosuppression ; IL-2 production ; CD4+ ; CD8+

Sažetak
Cyclosporine A (CysA) is a potent immunosuppressive agent, widely used for prevention of graft rejection in organ transplantation. It exerts immunosuppressive effect in vivo primarily due to its influence on the function of T cells. At which point exactly CysA affects T cell function is still unknown. In the present study we have investigated the effect of Cys A on the T cell proliferation and IL-2 production by CD4+ -enriched and CD8+ -enriched T cells, isolated from the spleen of normal mice. We found that the proliferation of CD8+ T cells was much more sensitive on the Cys A presence than CD4+ T cell proliferation. On the other hand, IL-2 production by CD4+ T cells was more affected by the Cys A presence than IL-2 production by CD8+ T cells. We suggest that there are at least two different models of Cys A action – one affecting IL-2 production and the other affecting T cell proliferation.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA