Pregled bibliografske jedinice broj: 989788
Improved virus safety and purity of a chromatographically produced Factor IX concentrate by nanofiltration
Improved virus safety and purity of a chromatographically produced Factor IX concentrate by nanofiltration // Journal of Chromatography B: Biomedical Sciences and Applications, 669 (1995), 2; 187-196 doi:10.1016/0378-4347(95)00107-t (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 989788 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Improved virus safety and purity of a chromatographically produced Factor IX concentrate by nanofiltration
Autori
Hoffer, L. ; Schwinn, H. ; Biesert, L. ; Josic, Dj.
Izvornik
Journal of Chromatography B: Biomedical Sciences and Applications (0378-4347) 669
(1995), 2;
187-196
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Factor IX ; Virus saftey ; Nanofiltration
Sažetak
A virus removal system based on tangential flow filtration was introduced into a Factor IX production process. Beside the intended virus reduction potency of filter membranes, an additional purification effect could be achieved. This purification effect was evaluated in detail by means of sodium dodecyl sulphate-polyacrylamide gel electrophoresis and size-exclusion HPLC. High-molecular-mass impurities were retained by the membrane, thus increasing the specific activity of the product.
Izvorni jezik
Engleski
Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
POVEZANOST RADA
Ustanove:
Sveučilište u Rijeci - Odjel za biotehnologiju
Citiraj ovu publikaciju:
Časopis indeksira:
- Scopus
