Naslov
Correlation of Histopathological and Serological Findings in Patients with Primary Sjṏgren Syndrome

Autori
Glavina, Ana ; Mravak-Stipetić, Marinka ; Markeljević, Jasenka ; Biočina-Lukenda, Dolores

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Sažeci 4. Međunarodnog kongresa Stomatološkog fakulteta Sveučilišta u Zagrebu u Acta Stomatologica Croatia, vol. 52(2) / - , 2018, 170-171

Skup
4. međunaroddni kongres Stomatološkog fakulteta Sveučilišta u Zagrebu

Mjesto i datum
Zagreb, Hrvatska, 02.03.2018. - 03.03.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Histopathological ; Serological Findings ; Primary Sjṏgren Syndrome

Sažetak
Aim: Biopsy of small labial salivary gland (SLSG) is a gold standard in the diagnosis of pri-mary Sjögren’s syndrome (pSjS). The aim of this pilot study was to determine the corre-lation between serological and histopathological findings in patients with xerostomia and suspected primary Sjögren’s syndrome to determine if biopsy (SLSG) is a mandatory or accompanying diagnostic test for Sjoegren’s syndrome.Materials and Methods: The study included 29 subjects, of whom 28 women and 1 male (median age 62, range 29 to 81 years) who were referred to serological diagnostics (anti-SSA, anti-SSB) and in which small labial salivary glands biopsy was performed. Positive histopathological finding was considered to be a focal spot finding more then 1.Results: Positive histopathological findings had ten (34%) patients. Positive autoantibod-ies to anti-SSA had 38% of respondents, anti-SSB 28%, and combination of anti-SSA and anti-SSB 24%. In all subjects with positive serological findings of anti-SSA, anti-SSB and their combination high correlation with positive histopathological findings (73-100%) was found. High sensitivity has been demonstrated for anti-SSA (100%), for anti-SSB (83%) and less for combination anti-SSA and anti-SSB (77%).Conclusion: Primary Sjögren syndrome has been demonstrated in a third of subjects with high correlation of positive histopathological findings and autoantibodies (anti-SSA, an-ti-SSB, and combination anti-SSA and anti-SSB). In the case of a positive antibodies titer finding, histopathological diagnosis may be a accompanying diagnostic test rather than mandatory taking into account the high sensitivity of antibodies to SSA and SSB and in cases when biopsy is contraindicated.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Dentalna medicina

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