Naslov
Targeting tumour metastasis: the emerging role of nanotechnology

Autori
Visentin, Sarah ; Sedić, Mirela ; Kraljević Pavelić, Sandra ; Pavelić, Krešimir

Izvornik
Current medicinal chemistry (0929-8673) 27 (2020), 8; 1367-1381

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cancer stem cells ; cancer therapy ; metastasis ; nanomedicine ; stem cell marker

Sažetak
Metastatic process has still not been completely elucidated, probably due to insufficient knowledge of the underlying mechanisms. Here, we provide an overview of the current findings that shed light on specific molecular alterations associated with metastasis and present novel concepts in the treatment of the metastatic process. In particular, we discuss novel pharmacological approaches in the clinical setting that target metastatic progression. New insights into the process of metastasis allow optimizing and designing new treatment strategies, especially when taking into account the fact that metastatic cells share common features with stem cells. Lastly, we touch upon nano- and micro-technologies in targeted drug delivery for metastatic cancer. The latter could provide more efficient way to tackle metastasis and thus bring about advancements in the treatment and management of cancer patients.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA