6-Amino-6-deoxyascorbic acid induces apoptosis in human tumor cells

Grdiša, Mira; Kralj, Marijeta; Eckert-Maksić, Mirjana; Maksić, Zvonimir B.; Pavelić, Krešimir

doi:10.1007/BF01202220

Pregled bibliografske jedinice broj: 989443

6-Amino-6-deoxyascorbic acid induces apoptosis in human tumor cells

Grdiša, Mira; Kralj, Marijeta; Eckert-Maksić, Mirjana; Maksić, Zvonimir B.; Pavelić, Krešimir

6-Amino-6-deoxyascorbic acid induces apoptosis in human tumor cells // Journal of cancer research and clinical oncology, 121 (1995), 2; 98-102 doi:10.1007/BF01202220 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 989443 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
6-Amino-6-deoxyascorbic acid induces apoptosis in human tumor cells

Autori
Grdiša, Mira ; Kralj, Marijeta ; Eckert-Maksić, Mirjana ; Maksić, Zvonimir B. ; Pavelić, Krešimir

Izvornik
Journal of cancer research and clinical oncology (0171-5216) 121 (1995), 2; 98-102

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
6-amino-6-deoxyascorbic acid ; Apoptosis Tumor cells

Sažetak
6-Amino-6-deoxyascorbic acid was found to inhibit human tumor cell growth. The antitumor effect depends on the tumor type and concentration of the acid. After cell treatment with 6-amino-6-deoxyascorbic acid, drastic morphological changes were found. Although image analysis did not show a difference in p53 and c- myc gene expression, the appearance of chromatin aggregation and DNA fragmentation points to apoptosis or programmed cell death.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Mirjana Maksić (autor)