Naslov
Low doses of cadmium and phthalates – cytotoxic and genotoxic properties

Autori
Huđek, Ana ; Rumenova Raychinova, Mirela ; Čurčić, Marijana ; Esteban Mozo, Javier ; Bačun-Družina, Višnja ; Durgo, Ksenija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
4th Congress of Croatian Geneticists with International Participation : Book of Abstract / Šarčević, Hrvoje ; Ugarković, Đurđica ; Vujaklija, Dušica ; Svetec, Ivan K. ; Svetec Miklenić, Marina - Zagreb : Hrvatsko genetičko društvo, 2018, 47-47

ISBN
978-953-57128-1-7

Skup
4th Congress of Croatian Geneticists with international participation

Mjesto i datum
Krk, Hrvatska, 26.09.2018. - 29.09.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
cadmium ; phthalates ; environmental contaminants ; genotoxic potential

Sažetak
Environmental contaminants often occur in the nature at low concentrations that are not considered to be toxic. Anyhow, their presence and, in some cases, persistence, can cause significant side effects on members of affected ecosystem. Cadmium and phthalates are often found in the environment in nanomolar concentrations. Cadmium is classified to be human carcinogen and phthalates are not directly acting genotoxic compounds. If there are indices of their tumorigenicity it is supposed that it is a result of nongenotoxic mechanism of action. Bis-2 ethylhexyl phthalate is widely used phthalate, and there are no experimental data concerning genotoxicity of environmentally significant concentrations. In this work, genotoxic potential of environmentally significant concentrations of both compounds and their mixtures were investigated on different human cell lines ; tongue carcinoma cell line, human colon carcinoma cells and human hepatocellular carcinoma cells during 2 and 4 hours of incubation. Expectedly, results of testing for cytotoxicity were negative, but mixtures of cadmium and DHEP caused cell proliferation. Also, it was noticed that mixtures caused formation of free radicals and certain DNA damage after different times of treatment, so it can be concluded that mixtures of nontoxic concentrations of contaminants, cadmium and DHEP, caused genotoxic effect.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija, Interdisciplinarne biotehničke znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

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