Naslov
Evidence-Based Laboratory Medicine: HowWell Do Laboratories Follow Recommendations and Guidelines? The Cardiac Marker Guideline Uptake in Europe (CARMAGUE) Study

Autori
Collinson, Paul ; van Dieijen-Visser, Marja ; Pulkk, Kari ; Hammerer-Lercher, Angelika ; Suvisaari, Janne ; Ravkilde, Jan ; Stavljenic- Rukavina, Ana ; Baum, Hansjorg ; LaitinenPaivi ;

Izvornik
Clinical chemistry and laboratory medicine (1434-6621) 58 (2012), 1; 305-314

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
evidence based ; laboratorymedicine ; cardiac marker guidelines

Sažetak
The original Cardiac MarkerGuideline Uptake in Europe (CARMAGUE) study (1 ) surveyed laboratory practice against the then current clinical practice recommendations.Responses were obtained from 303 laboratories in 28 countries.The responders were from a full range of laboratories: 34% universityhospital laboratories, 36% districthospitals, 25% central hospitals, and 5% primary care acilities.Ninety-five percent of the laboratories used troponin as the preferred marker for routine diagnosis of suspected acute coronary syndromes.Fifty percent of the laboratories use troponin T, and 45% used troponin I.Thirty-one percent of the laboratories used troponin as the sole marker, but 69% combined troponin measurement with another marker and offered other marker tests in suspected cases of acute coronary syndrom.The wide range of choice of decision limits may in part represent laboratory conservatism, physician resistance, or a feeling that assay performance is inadequate for using a 99th percentile value. There is a need for independent validation of both assay performance and 99th percentile values to provide decision limits for MI independent of manufacturers’.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA