Pregled bibliografske jedinice broj: 985388
Interactions of macrolides with their biological targets
Interactions of macrolides with their biological targets // Macrolides : properties, synthesis and applications / Arsić, Biljana (ur.).
Berlin: Walter de Gruyter, 2018. str. 63-77 doi:10.1515/9783110515756
CROSBI ID: 985388 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Interactions of macrolides with their biological targets
Autori
Novak, Predrag
Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni
Knjiga
Macrolides : properties, synthesis and applications
Urednik/ci
Arsić, Biljana
Izdavač
Walter de Gruyter
Grad
Berlin
Godina
2018
Raspon stranica
63-77
ISBN
978-3-11-051502-2
Ključne riječi
Macrolides ; interactions ; binding epitopes
Sažetak
Macrolide antibiotics are effective and well-tolerated therapeutic agents for treating infectious diseases owing to their high efficacy and safety. Macrolides bind to the ribosomal 23S rRNA in domain V at or near the peptidyl transferase region and block the exit tunnel through which the nascent peptides leave the ribosome. A crucial step in the discovery of novel compounds for preventing resistance is to understand the principles of how macrolides interact with their macromolecular targets. Hence, by applying one-and two-dimensional NMR experiments it is possible to characterise the interactions of macrolides and ribosomes and to determine the reactive groups responsible for binding. The two most commonly used NMR techniques to study macrolide binding are transferred nuclear Overhauser effect spectroscopy (trNOESY) and saturation transfer difference (STD) NMR experiments.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
