Naslov
The effect of the filler and layers on the properties of electrospun antibiotic/fibroin scaffolds

Autori
Zdraveva, Emilija ; Mijović, Budimir ; Holjevac Grgurić, Tamara ; Govorčin Bajsić, Emi ; Dekaris, Iva ; Tominac Trcin, Mirna ; Ujčić, Massimo ; Kaziur, Patrycja ; Maslanka, Paulina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts 12th International Textile Science and Economy - French-Croatian Forum / Novak, Ivan ; Schwarz, Ivana ; Špelić, Ivana ; Zdraveva, Emilija - Zagreb : Tekstilno-tehnološki fakultet Sveučilišta u Zagrebu, 2019, 42-43

ISBN
978-953-7105-73-0

Skup
12th International Scientific-Professional Symposium "Textile Science and Economy (TSE 2019)

Mjesto i datum
Zagreb, Hrvatska, 23.01.2019. - 24.01.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Electrospun scaffolds, PCL, antibiotic/fibroin, morphology, tensile properties

Sažetak
Functionalized electrospun materials have many applications one of which includes biomedicine or tissue engineering. These materials act as scaffolds as can simulate the extracellular matrix in tissues thus giving support to cells growth and finally helping tissue regeneration. This study gives an insight into the research concerning development of this type of materials as part of the Croatian Science Foundation project. Electrospun composite scaffolds were prepared by electrospinning of neat polycaprolactone (PCL), as well as PCL blended with an antibiotic or silk fibroin separately and finally by electrospinning both PCL/fibroin and PCL/antibiotic within a layered configuration. The scaffolds were analyzed in regard to their morphology, total porosity, surface wettability and tensile behaviour taking into account the type of filler and layered structure. Firstly the addition of the antibiotic as well as silk fibroin both resulted in the reduction of the water contact angle on the surface of the hydrophobic PCL. Thus, a hydrophilic surface is of paramount importance as it improves scaffolds cells adhesion. The addition of the fillers, antibiotic and silk fibroin, resulted in PCL fibers diameter reduction by 28% and increase by 224%, respectively. Fibers deformations or beads were present in case of the neat PCL and the PCL/fibroin fibers. The biggest pores area were in case of the PCL/fibroin of 8.13±6.45 µm2. The total porosity reduced gradually with the addition of the fillers, resulting in the lowest value in case of the layered scaffolds (from 94.2 to 68.5%). The tensile strength of the electrospun scaffolds improved with the addition of the antibiotic and in case of the layered structure, resulting in the maximum value of 260.33±60.53 cN/mm2. These results suggest that the nature of the filler affects its miscibility with the polymer and electrospinning jet stretching and both porosity and tensile strength are affected by the scaffolds composition and layered structure. In this way by variating the composition and physical structure, scaffolds can be designed according to requirements in tissue therapy and repair.

Izvorni jezik
Engleski

Znanstvena područja
Kemijsko inženjerstvo, Tekstilna tehnologija, Temeljne medicinske znanosti, Biotehnologija

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