Multicomponent Approach to a Library of N- Substituted γ-Lactams

Suć Sajko, Josipa; Ljoljić Bilić, Vanja; Kosalec, Ivan; Jerić, Ivanka

doi:10.1021/acscombsci.8b00147

Pregled bibliografske jedinice broj: 981103

Multicomponent Approach to a Library of N- Substituted γ-Lactams

Suć Sajko, Josipa; Ljoljić Bilić, Vanja; Kosalec, Ivan; Jerić, Ivanka

Multicomponent Approach to a Library of N- Substituted γ-Lactams // ACS Combinatorial Science, 21 (2019), 1; 28-34 doi:10.1021/acscombsci.8b00147 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 981103 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Multicomponent Approach to a Library of N- Substituted γ-Lactams

Autori
Suć Sajko, Josipa ; Ljoljić Bilić, Vanja ; Kosalec, Ivan ; Jerić, Ivanka

Izvornik
ACS Combinatorial Science (2156-8952) 21 (2019), 1; 28-34

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
antibiofilm activity ; multicomponent reactions ; Ugi reaction ; γ-lactams

Sažetak
The γ-lactam motif is often found in naturally occurring compounds with diverse biological activities. We prepared a 28-member library of N-substituted γ-lactams following a single-pot, three-component Ugi reaction comprising bifunctional building block, l-glutamic acid methyl ester. The reaction tolerates structurally diverse carbonyl and isocyanide components providing a robust access to functionalized γ-lactams. Antimicrobial susceptibility testing, including agar well diffusion assay, serial microdilution broth assay, and antibiofilm activity testing, identified a potent compound with antibiofilm activity against Staphylococcus aureus ATCC 6538.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA

Projekti:
HRZZ-IP-2014-09-3102 - Višekomponentne reakcije u sintezi peptidnih mimetika (MIMICRy) (Jerić, Ivanka, HRZZ - 2014-09) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb

Profili:

Ivan Kosalec (autor)