Naslov
Salivary Concentrations Of Antioxidants And Cortisol In Patients With Chronic Temporomandibular Disorders.
(Alivary Concentrations Of Antioxidants And Cortisol In Patients With Chronic Temporomandibular Disorders.)

Autori
Alajbeg, Ivan ; Vrbanović, Ema ; Lapić, Ivana ; Rogić, Dunja ; Alajbeg, Iva

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
14th Biennial congress of EAOM in conjunction with the world workshop on oral medicine VII.

Mjesto i datum
Göteborg, Švedska, 27.09.2018. - 29.09.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
temporomandibular disorders ; salivary diagnostics ; oxidative stress

Sažetak
Aim: Temporomandibular disorders’ (TMD) risk factors include mechanical and psychological stressors. The aim of this study was to investigate the relationship between salivary antioxidant parameters, salivary cortisol and TMD, i.e. to see if mentioned stressors are measurably affecting involved mechanisms. Methods: Twelve patients diagnosed with chronic TMD, and 15 systemically and periodontally healthy agematched controls were included. Five milliliters of whole unstimulated saliva was collected into a graduated tube twice a day: 7 AM and 5 PM. Salivary superoxide dismutase (SOD), and glutathione peroxidase (GPx), total antioxidant capacity (TAC) and uric acid (UA) were analyzed using spectrophotometric methods. Salivary cortisol was determined by enzyme- linked immunosorbent assay. Salivary biomarker concentrations between TMD and control groups were compared by T- test and the correlation among antioxidants’ and salivary cortisol concentrations by Pearson’s correlation analysis. Results: Significantly increased salivary concentrations of SOD (p<0.001) was found in TMD group, whereas the mean salivary concentrations of cortisol, GPx, TAC and UA, although higher in the TMD group, were not statistically significant. There was a highly significant positive correlation (p<0.05) between salivary cortisol levels and antioxidant parameters in TMD patients. Conclusion: Contrary to earlier studies showing lower concentrations of anti-oxidant enzymes in TMD patients, indicating that a lack of anti- oxidant defense leads towards TMD, we observed trends towards higher levels of antioxidants in TMD patients. This represents compensatory mechanisms as response to higher level of stress, which could be extrinsic and leading towards TMD, or intrinsic stress emerging from established TMD, or both.

Izvorni jezik
Engleski

Znanstvena područja
Dentalna medicina

POVEZANOST RADA