Naslov
Comparison of inflammatory stress response between laparoscopic and open approach for pediatric inguinal hernia repair in children

Autori
Jukić, Miro ; Pogorelić, Zenon ; Šupe-Domić, Daniela ; Jerončić, Ana

Izvornik
Surgical endoscopy (0930-2794) 33 (2019); 3243-3250

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
percutaneous internal ring suturing - PIRS ; inguinal hernia ; children ; interleukin 6 - IL-6 ; tumor necrosis factor alpha - TNF-α ; surgical inflammatory stress response

Sažetak
Background The aim of this study was to compare inflammatory stress response between laparoscopic percutaneous inguinal ring suturing (PIRS) and open modified Marcy technique for pediatric inguinal hernia repair. Methods From May 2017 to April 2018, 32 male children with median age of 4.5 years undergoing inguinal hernia repair were included in randomized controlled trial. The patients were divided in two groups, by using random number generator, depending on surgical approach. The blood was tested in three time frames for white blood cells count (WBC), C- reactive protein (CRP), Interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α). Results Significant increase in concentration for all inflammatory biomarkers, that occur over time, has been found (p < 0.001 for all). Additionally, it was also found that the type of surgery significantly influenced the level of WBC, CRP, and IL-6 with Marcy showing a higher level of inflammatory response (WBC 11.4 ± 3.1 × 109/L ; CRP 11.5 mg/L ; IL-6 11.0 pg/mL) than the PIRS (WBC 7.6 ± 1.6 × 109/L ; CRP 0.8 mg/L ; IL-6 2.0 pg/mL) (p < 0.001 for all). Similar pattern was also found for TNF-α (Marcy 16.8 pg/mL ; PIRS 10.1 pg/mL), but correlation between surgery type and concentration of this biomarker was significant only at the 0.1 level (p = 0.055). The mean operation time was significantly shorter (9 ± 2 min) in PIRS group compared to Marcy group (25 ± 7 min) (p < 0.001). Significantly lower median of visual analog scale score (VAS) was found in PIRS group (VAS = 2) compared to Marcy group (VAS = 6) (p < 0.001). Conclusions Use of laparoscopic (PIRS) technique in children shows significantly lower surgical stress in comparison to open hernia repair.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

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