Naslov
HDL subclasses and mortality in acute heart failure patients

Autori
Degoricija, Vesna ; Potočnjak, Ines ; Gastrager, Michaela ; Pregartner, Gudrun ; Berghold, Andrea ; Scharnagl, Hubert ; Stojaković, Tatjana ; Tiran, Beate ; Marsche, Gunther ; Frank, Saša

Izvornik
Clinica chimica acta (0009-8981) 490 (2019), March 2019; 81-87

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
HDL3 cholesterol ; HDL particles ; Homogeneous assays ; Outcome

Sažetak
The link between HDL subclasses and the prognosis of cardiovascular diseases remains controversial. We thus evaluated the prognostic value of the HDL subclasses 3 and 2 cholesterol (HDL3-C, HDL2-C) as well as of total HDL-C for 3-month mortality in acute heart failure (AHF) patients. The serum levels of HDL3-C and total HDL-C were determined by detergent-based homogeneous assay. HDL2-C was computed by the difference between total HDL-C and HDL3-C. Out of the 132 analyzed patients, 35 (26.5%) died within three months after onset of AHF. Univariate logistic regression analyses revealed a significant inverse association of HDL3-C (odds ratio (OR) 0.46 per 1-SD increase, 95% confidence interval (CI) 0.27–0.72, p = 0.001) with 3-month mortality, whereas concentrations of total HDL-C and HDL2-C showed no significant association. After adjustment for various laboratory and clinical parameters known to be associated with mortality in heart failure patients, HDL3-C concentrations remained significantly associated with 3-month mortality (OR 0.34 per 1-SD increase, 95% CI 0.15–0.74, p =0.010). We conclude that low admission serum levels of HDL3-C are associated with an increased 3-month mortality in AHF patients, whereas total HDL-C and HDL2-C showed no association. HDL3-C might thus be useful as a prognostic parameter in AHF.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
This research was supported by the Austrian Science Foundation [P27166-B23 to SF], and the Jubilee Foundation of the Austrian National Bank [15858 to SF]. The funders had no roles in the design of the study, data collection, analysis, and interpretation, report writing or article submission.

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