Naslov
Proportion and laminar distribution of calretinin neurons in the monkey prefrontal cortex

Autori
Sedmak, Dora ; Scapula Jennyfer ; Dzaja Domagoj ; Petanjek, Zdravko ; Esclapez, Monique

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, ostalo, znanstveni

Skup
Society for Neuroscience 2017

Mjesto i datum
Washington D.C., Sjedinjene Američke Države, 11.11.2017. - 15.11.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
cerebral cortex, GABA, calretinin, human, monkey

Sažetak
Previous studies in primate associative cortex have shown that calretinin neurons represent 12% of the total neuronal pool whereas in rodents their proportion does not exceed 3%. However it is still unclear whether such high proportion of calretinin neurons is a general feature of all primate cortical areas, whether it is layer specific and whether all these calretinin neurons are GABAergic. To address these questions we performed a quantitative study of calretinin neurons within three phylogenetically and functionally different areas of the macaque monkey prefrontal cortex (Brodmann areas 24, 32 and 9). Our results showed that calretinin labelled neurons represent around 15% of the total number of neurons revealed by NeuN immunolabelling in all examined cortical areas. Calretinin neurons were mostly located (75%) in the upper cortical layers. They account for 50% of total number of the neurons in layer I ; 30% in layer II and 20% in layer III. Simultaneous immunohistochemical detection of calretinin with parvalbumin, or calbindin, showed that the population of calretinin neurons does not overlap with the other two major subpopulations of GABAergic neurons. It further demonstrated that calretinin neurons are at two times more numerous than the population of parvalbumin neurons and of calbindin neurons. These three subpopulations of GABAergic neurons account for 25% of all cortical neurons in the primate prefrontal cortex. Our data indicated that the high proportion of calretinin neurons in the upper cortical layers is a general feature of the primate prefrontal cortex. It suggests that this subpopulation of GABAergic neurons is instrumental to control information processing of a more complex cortico-cortical neuronal network.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA