Naslov
Remineralization effect of hydroxyapatite and its potential for substituting fluoride in dentifrice

Autori
Maretić, Ivana ; Peroš, Kristina ; Šutej, Ivana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Book of Abstracts V International Conference on Antimicrobial Research - ICAR2018 / - , 2018, 74-75

Skup
5th International Conference on Antimicrobial Research (ICAR2018)

Mjesto i datum
Málaga, Španjolska; Torremolinos, Španjolska, 24.05.2018. - 25.05.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Recenziran

Ključne riječi
remineralization ; enamel ; hydroxyapatite

Sažetak
Prevention is still main focus and the best method for fighting the caries. The lack of education makes this approach more difficult and leads to the increase use of unfluoridated dentifrice. Fluoride is known as a successful remineralization agent. However, lack of remineralization in hyposalivation conditions, lower efficiency of mineralization of fissure caries and danger of dental fluorosis motivated scientists to find a remineralization agent that could substitute its role. Consequently, today many dentifrices contain newly found remineralization agents like calcium and phosphate ions and compounds such as casein phosphopeptideamorphous calcium phosphate (CPP- ACP), tricalcium phosphate (TCP), xylitol and hydroxyapatite. The composition of unfluoridated dentifrice with an emphasis on remineralization agents and remineralisation effects were investigated by literature search. Due to the increased number of promising results in the revised researches, inquiry was emphasised on the hydroxyapatite. Literature search was conducted on PubMed website with key words: enamel and remineralization. Given the limitation of last 10 years and excluding the reviews, search showed total of 887 results of clinical and preclinical studies. More than half of investigations, involved fluoride as reminerallization agent, followed by agents containing calcium phostphate compounds. Lastly, researches with hydroxyapatite as most recent agent used for enamel remineralization investigated, was used in 112 articles. Studies of CPP-ACP, tricalcium phosphate xylitol and hydroxyapatite showed promising results in remineralization. Moreover, hydroxyapatite was distinguished as a better alternative to fluoride compared to other calcium compounds Hydroxyapatite has demonstrated exceptional biocompatibility and affinity to dental enamel. The main disadvantages of hydroxyapatite are lack of strength, fragility and poor solubility in neutral pH. For this reason, particles of hydroxyapatite were synthesized in various forms, sizes and combinations with other elements such as zinc and strontium. In many studies, it has shown lesser or equal remineralization effects compared to fluorine. However, it is necessary to highlight that the results varied, where hydroxyapatite showed better results when biofilm or saliva was integrated in the remineralization model. At the same time remineralization proved to be more successful at lower pH values. There is a need for further research of mechanisms of hydroxyapatite remineralization given that potential exists. During the literature research, diversity in methodology has been observed, from tooth selection to choice of analytical method. This diversity makes it difficult to compare studies and make conclusions about the real remineralization effect. Therefore, more in vivo research and better consent of scientists in selection of methods are needed.

Izvorni jezik
Engleski

Znanstvena područja
Dentalna medicina

POVEZANOST RADA