Naslov
Genome rearrangements in radiation-resistant bacteria

Autori
Repar, Jelena ; Supek, Fran ; Klanjscek, Tin ; Warnecke, Tobias ; Zahradka, Ksenija ; Zahradka, Davor

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
4th Congress of Croatian Geneticists with international participation : Book of Abstracts / Šarčević, Hrvoje ; Ugarković, Đurđica ; Vujaklija, Dušica ; Svetec, Ivan Krešimir ; Svetec Miklenić, Marina - Zagreb : Hrvatsko genetičko društvo, 2018, 24-24

ISBN
978-953-57128-1-7

Skup
4th Congress of Croatian Geneticists with international participation

Mjesto i datum
Krk, Hrvatska, 26.09.2018. - 29.09.2018

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Recenziran

Ključne riječi
genome rearrangments ; gene order ; radiation-resistant species ; DNA double-strand breaks

Sažetak
A number of bacterial, archaeal, and eukaryotic species are known for their resistance to ionizing radiation. One of the challenges these species face is a potent environmental source of DNA double-strand breaks, potential drivers of genome structure evolution. Efficient and accurate DNA double-strand break repair systems have been demonstrated in several unrelated radiation- resistant species and are putative adaptations to the DNA damaging environment. Such adaptations are expected to compensate for the genome- destabilizing effect of environmental DNA damage and may be expected to result in a more conserved gene order in radiation-resistant species. However, we show that rates of genome rearrangements, measured as loss of gene order conservation with time, are higher in radiation- resistant species in multiple, phylogenetically independent groups of bacteria. Furthermore, we explore whether detected high rearrangement rates in radiation-resistant species constitute a survival strategy or are a passive consequence of environmental DNA damage.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA