Naslov
Arterial stiffness as a measure of cardiovascular risk in obese adolescents and adolescents with diabetes type 1

Autori
Putarek, Krešimir ; Banfić, Ljiljana ; Pašalić, Marijan ; Krnić, Nevena ; Špehar Uroić, Anita ; Rojnić Putarek, Nataša

Izvornik
Journal of pediatric endocrinology & metabolism (0334-018X) 31 (2018), 12; 1315-1323

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
adolescents ; arterial stiffness ; cardiovascular risk ; diabetes type 1 ; obesity.

Sažetak
Background: Cardiovascular disease (CVD) is the end result of vascular aging and atherosclerosis, having its origins in childhood. The aim of our study was to compare arterial stiffness (AS) and intima-media thickness (IMT) as markers of an early vascular damage between obese adolescents, adolescents with diabetes type 1 (T1D) and lean control subjects. Methods: We analyzed AS and IMT in 68 obese adolescents (13.27 ± 2.31 years), 42 adolescents with T1D (14.95 ± 2.35 years) lasting over 5 years and 38 controls (15.02 ± 1.94 years). AS (measured by pulse wave velocity [PWV], arterial compliance [AC] and β-stiffness) and IMT were assessed using an e-tracking ultrasound method. Results: A significant difference between the groups was found for AC (p = 0.022) and PWV (p = 0.010), with the lowest compliance and higher velocities in T1D patients. When corrected for age, the difference in AC among the groups did not reach a statistical difference (p = 0.059). Correlation analysis in the obese adolescents showed lower AC in females (p = 0.041), with higher systolic blood pressure (SBP) (p = 0.032). In T1D adolescents, disease duration was the strongest determinant of AS (AC p = 0.028, β p = 0.029 and PWV p = 0.003), followed by body mass index (BMI ; PWV p = 0.008 ; β p = 0.033), SBP (AC p < 0.001 ; PWV p = 0.023), diastolic BP (AC p = 0.049 ; PWV p = 0.048) and HbA1c (PWV p = 0.048). No significant correlations were found for AS measures or IMT with sex, age, BMI, Tanner stage or BP levels in controls. Conclusions: Early vascular damage is more pronounced in T1D adolescents than in obese or lean adolescents, which may emphasize the impact of hyperglycemia as a major threat for cardiovascular health.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA