Naslov
Comparason of the levels of insulin-like growth factor I (IGF-I) in aqueus fluid and serum with grades of retinopathy in patients with diabetes mellitus

Autori
Kaštelan, Snježana ; Bušić, Mladen ; Zjačić-Rotkvić, Vanja ; Krpan, Ružica ; Krpan, I ; Petek, Maja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
3. Kongres Hrvatskog oftalmološkog društva s međunarodnim sudjelovanjem. / - , 2003, 23-23

Skup
3. Kongres Hrvatskog oftalmološkog društva s međunarodnim sudjelovanjem.

Mjesto i datum
Rovinj, Hrvatska, 15.05.2003. - 17.05.2003

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
diabetic retinopathy, insulin-like growth factor I, aqueous fluid, serum, concentration

Sažetak
Aims: To determine the relationship between the stages of diabetic retinopathy (DR) and the levels of insulin-like growth factor I (IGF-I) in aqueous fluid and serum. Methods: Levels of the IGF-I in serum and aqueous humour obtained during cataract surgery were measured by radioimmuno assay coated tubes (RIA-CT) in 28 diabetic patients with 10 non-diabetic patients (NDM) as controls. The patients with diabetes were classified into three groups according to the stage of DR: no DR (NDR ; 10 cases), non-proliferative DR (NPDR ; 10 cases), and proliferative DR (PDR ; 8 cases). Results: No significant differences were found between any of the groups in serum concentration of IGF-I. The aqueous IGF-I levels increased with the stage of DR Conclusion. The result of our study suggests that IGF-I localy present in the ocular tissues may play roles in the progression of diabetic retinopathy.

Izvorni jezik
Hrvatski, engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA