Naslov
Biomarkeri i glaukom
(Biomarkers in glaucoma)

Autori
Salopek Rabatić, Jasminka ; Kaštelan, Snježana ; Knezović, Igor

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
15. Kongres Hrvatskog oftalmološkog društva s međunarodnim sudjelovanjem. / - , 2015, 77-77

Skup
15. Kongres Hrvatskog oftalmološkog društva s međunarodnim sudjelovanjem.

Mjesto i datum
Vodice, Hrvatska, 14.05.2015. - 17.05.2015

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
biomarkers, glaucoma, early detection, treatment, progression

Sažetak
Aim A biomarker is an indicator of a biological condition that, in some cases, can assist in the diagnosis and management of disease. Molecular biomarkers have yet to be explored in glaucoma. Currently, in the management of glaucoma we look at structure and function of the nerve tissue at the back of the eye. We try to evaluate if the patient’s retina or optic nerve is losing tissue and whether this is accompanied by diminished sensitivity to light across the visual fields. Patients and methods A thorough PUBMED search for literature review was done in order to find up to date / newest data after the ARVO Foundation for Eye research meeting in 2011 – when the milestone was set for this topic. Results The increased sensitivity and accuracy of genomic, proteomic, and metabolomic techniques have brought about the potential to identify molecular entities that may serve as potentially useful markers, including (1) markers for early detection of a disease ; (2) markers that will predict severity of a disease ; (3) markers that will predict the rate of disease progression, and (4) markers that will serve as predictors of response to treatment. We identified: genetic biomarkers, proteomic biomarkers, pre-immune and immune events, all of them challenging in complexity. At the moment in Croatia, in our everyday practice we must lean on IOP measurements / frequency of control visits and VF defects progression, according to EGS 2014. guidelines. Conclusion The Glaucoma Research Foundation will be emphasizing research into biomarkers for glaucoma to stimulate activity in this area. The identification of a metabolic marker indicating tissue injury with accuracy could potentially help predict glaucoma in patients who do not yet show symptoms of vision loss (pre perimetric glaucoma). Such a marker could help doctors treating glaucoma know whether the patient is likely to progress and therefore treat the disease more aggressively or whether treatment is even required in certain patients.

Izvorni jezik
Hrvatski, engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA