Naslov
Herpes Simplex Virus 1 Deregulation of Host MicroRNAs

Autori
Cokarić Brdovčak, Maja ; Zubković, Andreja ; Jurak, Igor

Izvornik
Non-Coding RNA (2311-553X) 4 (2018), 4; 36, 21

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
HSV-1, miRNA

Sažetak
Viruses utilize microRNAs (miRNAs) in a vast variety of possible interactions and mechanisms, apparently far beyond the classical understanding of gene repression in humans. Likewise, herpes simplex virus 1 (HSV-1) expresses numerous miRNAs and deregulates the expression of host miRNAs. Several HSV-1 miRNAs are abundantly expressed in latency, some of which are encoded antisense to transcripts of important productive infection genes, indicating their roles in repressing the productive cycle and/or in maintenance/reactivation from latency. In addition, HSV-1 also exploits host miRNAs to advance its replication or repress its genes to facilitate latency. Here, we discuss what is known about the functional interplay between HSV- 1 and the host miRNA machinery, potential targets, and the molecular mechanisms leading to an efficient virus replication and spread.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA