Naslov
CRIBS cohort: a base for family-based disease risk prediction.

Autori
Bočkor, Luka ; Dolanc, Ivan ; Carić, Tonko ; Šarac, Jelena ; Novokmet, Natalija ; Čoklo, Miran ; Missoni, Saša

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts EAA 2018. / - , 2018, 18-19

Skup
21st Congress of the European Anthropological Association

Mjesto i datum
Odense, Danska, 22.08.2018. - 25.08.2018

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Birth cohorts, genetic variants, metabolic syndrome, disease risk prediction

Sažetak
During the last decade it has become increasingly evident that genetic variants can explain only a portion of individual's susceptibility to non-communicable complex diseases. The spotlight of research therefore shifted to mechanisms of epigenetic modifications as central players in gene- environment interplay. The transgenerational propagation of both genetic variants and epigenetic programming can contribute to an increased risk of complex diseases. In this work we are presenting data of 150 mother-child dyads collected within the longitudinal CRIBS study focusing on the main constituents of the metabolic syndrome (cardiovascular diseases and obesity), but also other diseases that emerge in family history. We show incidence of diseases in mother’s families, biochemical parameters of mothers related to diseases and a plan of risk prediction and possible interventions based on environ-mental exposure and hereditary factors in mothers and their offspring.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Kliničke medicinske znanosti, Etnologija i antropologija

POVEZANOST RADA