Naslov
The Significance of Ki-67 in Head and Neck Cancers: Review Article

Autori
Žužul, Ivona ; Pavić, Ivana ; Granić, Marko ; Kuna, Tihomir ; Kotarac Knežević, Ana ; Andabak Rogulj, Ana

Izvornik
Research journal of pharmaceutical, biological and chemical sciences (0975-8585) 9 (2018), 6; 34-38

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
Ki-67 ; head and neck cancer ; molecular marker ; prognosis

Sažetak
Widely accepted prognostic factors like lymph node status, tumor size and cell differentiation sometimes are not useful in oral cancer diagnostics and prognosis. Therefore, study of tumor heterogeneity which involves also molecular markers might be useful in order to explain mechanisms of appearance and recurrences of oral squamous cell cancer. The aim of the present study was to search published literature in the last 25 years regarding the role of Ki-67 in the head and neck cancers. Thirty seven articles were included and results showed that Ki-67 is not reliable prognostic marker for oral squamous cell carcinoma because of contradictory results of the available studies.

Izvorni jezik
Engleski

Znanstvena područja
Dentalna medicina

POVEZANOST RADA