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Pregled bibliografske jedinice broj: 965822

Photodeamination to quinone methides in cucurbit[n]urils: potential application in drug delivery

Škalamera, Đani; Matković, Marija; Uzelac, Lidija; Kralj, Marijeta; Mlinarić-Majerski, Kata; Bohne, Cornelia; Basarić, Nikola
Photodeamination to quinone methides in cucurbit[n]urils: potential application in drug delivery // Organic & biomolecular chemistry, 16 (2018), 46; 8908-8912 doi:10.1039/C8OB02605J (međunarodna recenzija, članak, znanstveni)

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Naslov
Photodeamination to quinone methides in cucurbit[n]urils: potential application in drug delivery

Autori
Škalamera, Đani ; Matković, Marija ; Uzelac, Lidija ; Kralj, Marijeta ; Mlinarić-Majerski, Kata ; Bohne, Cornelia ; Basarić, Nikola

Izvornik
Organic & biomolecular chemistry (1477-0520) 16 (2018), 46; 8908-8912

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Drug delivery ; Cucurbit[n]uril ; Host-guest complexes ; Photochemistry ; Quinone methide ; Supramolecular chemistry ; Time-resolved spectroscopy

Sažetak
We demonstrate a proof of principle for a new approach in the development of a drug delivery system. Positively charged prodrug (phenol) can form stable inclusion complex with CB[7], which enables more efficient delivery of the prodrug. After photochemical transformation (photoactivation) inside the complex, an active drug quinone methide (QM) is formed and released from the complex, since it is neutral molecule and forms less stable complex with CB[7].

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
HRZZ-IP-2013-11-5660 - Mulitidisciplinarni pristup otkriću lijekova s ciljanim djelovanjem na matične stanice tumora – uloga transporta kalija (MultiCaST) (Kralj, Marijeta, HRZZ - 2013-11) ( CroRIS)
HRZZ-IP-2014-09-6312 - Supramolekulska kontrola fotokemijskih reakcija eliminacije (SupraPhotoE) (Basarić, Nikola, HRZZ - 2014-09) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Nikola Basarić (autor)

Avatar Url Marija Matković (autor)

Avatar Url Lidija Uzelac (autor)

Avatar Url Đani Škalamera (autor)

Avatar Url Marijeta Kralj (autor)

Avatar Url Kata Majerski (autor)

Poveznice na cjeloviti tekst rada:

doi pubs.rsc.org pubs.rsc.org

Citiraj ovu publikaciju:

Škalamera, Đani; Matković, Marija; Uzelac, Lidija; Kralj, Marijeta; Mlinarić-Majerski, Kata; Bohne, Cornelia; Basarić, Nikola
Photodeamination to quinone methides in cucurbit[n]urils: potential application in drug delivery // Organic & biomolecular chemistry, 16 (2018), 46; 8908-8912 doi:10.1039/C8OB02605J (međunarodna recenzija, članak, znanstveni)
Škalamera, Đ., Matković, M., Uzelac, L., Kralj, M., Mlinarić-Majerski, K., Bohne, C. & Basarić, N. (2018) Photodeamination to quinone methides in cucurbit[n]urils: potential application in drug delivery. Organic & biomolecular chemistry, 16 (46), 8908-8912 doi:10.1039/C8OB02605J.
@article{article, author = {\v{S}kalamera, \DJani and Matkovi\'{c}, Marija and Uzelac, Lidija and Kralj, Marijeta and Mlinari\'{c}-Majerski, Kata and Bohne, Cornelia and Basari\'{c}, Nikola}, year = {2018}, pages = {8908-8912}, DOI = {10.1039/C8OB02605J}, keywords = {Drug delivery, Cucurbit[n]uril, Host-guest complexes, Photochemistry, Quinone methide, Supramolecular chemistry, Time-resolved spectroscopy}, journal = {Organic and biomolecular chemistry}, doi = {10.1039/C8OB02605J}, volume = {16}, number = {46}, issn = {1477-0520}, title = {Photodeamination to quinone methides in cucurbit[n]urils: potential application in drug delivery}, keyword = {Drug delivery, Cucurbit[n]uril, Host-guest complexes, Photochemistry, Quinone methide, Supramolecular chemistry, Time-resolved spectroscopy} }
@article{article, author = {\v{S}kalamera, \DJani and Matkovi\'{c}, Marija and Uzelac, Lidija and Kralj, Marijeta and Mlinari\'{c}-Majerski, Kata and Bohne, Cornelia and Basari\'{c}, Nikola}, year = {2018}, pages = {8908-8912}, DOI = {10.1039/C8OB02605J}, keywords = {Drug delivery, Cucurbit[n]uril, Host-guest complexes, Photochemistry, Quinone methide, Supramolecular chemistry, Time-resolved spectroscopy}, journal = {Organic and biomolecular chemistry}, doi = {10.1039/C8OB02605J}, volume = {16}, number = {46}, issn = {1477-0520}, title = {Photodeamination to quinone methides in cucurbit[n]urils: potential application in drug delivery}, keyword = {Drug delivery, Cucurbit[n]uril, Host-guest complexes, Photochemistry, Quinone methide, Supramolecular chemistry, Time-resolved spectroscopy} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Arts & Humanities Citation Index (A&HCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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