Naslov
Muscle: An endocrine organ linking physical activity and development of chronic non- communicable diseases/diabetes mellitus.

Autori
Cigrovski Berković, Maja ; Bilić-Čurčić, Ines ; Herman Mahečić, Davorka ; Ružić, Lana ; Cigrovski, Vjekoslav

Izvornik
Endocrine oncology and metabolism (1849-8922) 3 (2017), 4; 119-123

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
cardiovascular outcome ; chronic inflammation ; diabetes type 2 ; muscles ; myokines

Sažetak
Sedentary lifestyle is one of the principal causes of non-communicable diseases worldwide. Recently, muscles have been recognized as an important source of cytokines and myokines, molecules with autocrine, paracrine, and endocrine function, and far-reaching effects. It has been postulated that muscles through cytokines can modulate low-grade chronic inflammation, a feature of non- communicable diseases, such as type 2 diabetes, and therefore play an important role in disease postponement and successful treatment. Therefore, physical activity is an integral part of treatment guidelines for type 2 diabetes. Despite increasing evidence of anti- inflammatory effect of PA, much more research is needed to pinpoint the type and intensity of activity with the largest anti- inflammatory effect, as well as the type of patients which would benefit most from this approach, especially in terms of improvement of cardiovascular outcomes.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Kineziologija

POVEZANOST RADA