Naslov
Inorganic zeolite cation exchangers and their biological effects in vivo

Autori
Kraljević Pavelić, Sandra

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
17. Ružičkini dani

Mjesto i datum
Vukovar, Hrvatska, 19.09.2018. - 21.09.2018

Vrsta sudjelovanja
Plenarno

Vrsta recenzije
Nije recenziran

Ključne riječi
innorganic cation exchanger ; in vitro ; in vivo

Sažetak
Zeolites are alumosilicate widely exploited in a number of industrial processes due to their porous structure and ion-exchange properties. More than 200 zeolites have been documented by The Structure Commission of the International Zeolite Association comprising more than 40 naturally occurring zeolites. The mineral assemblies of the most common zeolite occurrences in nature are clinoptilolite- and mordenite-containing tuffs, in which the zeolite clinoptilolite and mordenite content is high (80% and over). This is relevant as the only natural zeolite used for medical purposes in animals and humans so far is the non-toxic, natural zeolite clinoptilolite. Clinoptilolite is usually processed for medical applications in vivo by use of tribomechanical procedures that increase the material surface area. As different procedures used for the material processing are known to change physical-chemical properties of the material, i.e. Si to Al ratio on the surface, the effects in vivo are expected to be affected by these changes especially if taking into account the hypothesis that some of important biological effects of clinoptilolite observed in vivo are due to release of soluble silica from the surface. In this presentation therefore, a brief overview will be given on physical-chemical characteristics of three clinoptilolite materials obtained by different production methods in comparison with synthetic zeolite A. Aluminum-detoxification properties of these materials in vivo on a model of AlCl3 intoxicated rats will be presented as well. Further on, an overview on clinoptilolite applications in veterinary and human medicine will be provided along with presentation of own data from two clinical trials on humans by use of micronized clinoptilolite PMA. Results obtained within the first clinical trial aimed to monitor the mineral metabolism on healthy volunteers, proved the safety of PMA as no substantial or clinically relevant alterations in biochemical and haematological parameters or physiological metal concentrations upon PMA intake or that may be attributable to PMA were observed. The second double-blinded clinical trial performed on osteoporosis patients, proved PMA effectiveness as an intervention for bone regeneration in humans as all measured clinical parameters proved statistically better in the PMA-treated group which encourages the usage of PMA as a new valuable contribution to the treatment of osteoporosis alone or in a combined therapy regimen due to positive effects on bones/osteoporosis.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti

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