Pregled bibliografske jedinice broj: 963387
Mikrovalna sinteza kvaternih soli nikotinamida sa supstituiranim fenacil-bromidima
Mikrovalna sinteza kvaternih soli nikotinamida sa supstituiranim fenacil-bromidima // Book of Abstracts 17th Ružička Days / Tomas, S ; Ačkar, Đ (ur.).
Osijek : Zagreb: Prehrambeno tehnološki fakultet Sveučilišta Josipa Jurja Strossmayera u Osijeku ; Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2018. str. 34-34 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 963387 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Mikrovalna sinteza kvaternih soli nikotinamida sa supstituiranim fenacil-bromidima
(Microwave synthesis of nicotinamide quaternary salts with substituted phenacyl bromides)
Autori
Gašo-Sokač, Dajana ; Đurin, Antonija ; Šrajer Gajdošik, Martina ; Bušić, Valentina
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Book of Abstracts 17th Ružička Days
/ Tomas, S ; Ačkar, Đ - Osijek : Zagreb : Prehrambeno tehnološki fakultet Sveučilišta Josipa Jurja Strossmayera u Osijeku ; Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2018, 34-34
ISBN
978-953-7005-57-3
Skup
17. Ružičkini dani "Danas znanost - sutra industrija"
Mjesto i datum
Vukovar, Hrvatska, 19.09.2018. - 21.09.2018
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
kvaternizacija, kvaterne piridinijueve soli, mikrovalna sinteza, zelena kemija
(quaternization, quaternary pyridinium salts, microwave synthesis, green chemistry)
Sažetak
Quaternary salts of heterocyclic amines like nicotinamide have a wide range of terapeutic effects, they have been used as antibacterial and anticarcinogenic agents. The conventional methods of quaternization reaction are mainly performed with a large excess of solvent, and they take a long time. Reaction of quaternization under microwave heating of nicotinamide with substituted phenacyl bromides in acetone are reported. The reaction time was shortened, a better yield of the product was obtained and the reaction was more efficient. The synthesis yield by microwave heating in acetone is compared to conventional heating. Since the reaction of formation of nicotinamide salts belongs to the reaction of nucleophilic substitution (SN2) the yield of the product is affected by the structure of boath reagents, nicotinamide and electrophiles. The influence of electrophile structure on the quaternization reaction yield was investigated. Electrophiles are phenacyl bromides with different electron withdrawing and electron donating substituents in para- and ortho - position.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Ustanove:
Prehrambeno-tehnološki fakultet, Osijek,
Sveučilište u Osijeku - Odjel za kemiju
