Naslov
Grinding as Solvent-Free Green Chemistry Approach for Cyclodextrin Inclusion Complex Preparation in the Solid State

Autori
Jug, Mario ; Mura, Paola Angela

Izvornik
Pharmaceutics (1999-4923) 10 (2018), 4; 189-211

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
grinding ; mechanochemical activation ; cyclodextrins ; inclusion complexes ; amorphization ; solid state interaction ; solubility ; dissolution

Sažetak
Among the different techniques proposed for preparing cyclodextrin inclusion complex in thesolidstate, mechanochemicalactivationbygrindi ngappearsasafast, highlyefficient, convenient, versatile, sustainable, and eco-friendly solvent-free method. This review is intended to give a systematic overview of the currently available data in this field, highlighting both the advantages as well as the shortcomings of such an approach. The possible mechanisms involved in the inclusion complex formation in the solid state, by grinding, have been illustrated. For each type of applied milling device, the respective process variables have been examined and discussed, together with the characteristics of the obtained products, also in relation with the physicochemical characteristics of boththedrugandcyclodextrinsubjectedtogrinding. Thecriticalprocessparameterswereevidenced in order to provide a useful guide for a rational selection of the most suitable conditions for an efficient inclusion complex preparation by grinding, with the final purpose of promoting a wider use of this effective solvent-free cyclodextrin inclusion complex preparation method in the solid state.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA