Naslov
Sinteza, spektroskopska karakterizacija i citostatska ispitivanja novih 1, 2, 3-triazolil-kumarina i bis-(kumarin-triazolil)benzena
(Synthesis, spectroscopic characterization and cytostatic evaluation of novel 1, 2, 3-triazolyl-coumarins and bis-(coumarin-triazolyl)benzenes)

Autori
Bobanović, Kristina ; Kralj, Marijeta ; Uzelac Lidija ; Steinberg, Ivana ; Krištafor, Svjetlana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
17. Ružičkini dani "Danas znanost – sutra industrija" : knjiga sažetaka = 17th Ružička days "Today science – tomorrow industry" : Book of Abstracts / Tomas, Srećko ; Ačkar, Đurđica - Osijek : Prehrambeno tehnološki fakultet Sveučilišta Josipa Jurja Strossmayera u Osijeku ; Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2018, 20-20

ISBN
978-953-7005-57-3

Skup
17. Ružičkini dani "Danas znanost - sutra industrija"

Mjesto i datum
Vukovar, Hrvatska, 19.09.2018. - 21.09.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
1, 2, 3-triazole ; coumarin ; spectroscopic characterization ; cytostatic activity

Sažetak
Coumarins and 1, 2, 3-triazole rings have attracted considerable attention in the fields of biology, medicine and material science as components of biologicaly active compounds and ligands in fluorescent metal sensors due to their favourable photophysical properties [1]. In this work we report the synthesis, cytostatic evaluation and spectroscopic study of novel coumarin-triazole heterocycles as well as 1, 3- and 1, 4 -bis(coumarin-triazolyl)benzenes. All compounds are tested against human carcinoma cell lines. Interaction of some representatives with ct-DNA is studied by UV-vis and fluorescence spectroscopy. All compounds were evaluated as potential chemosensing molecules for pH and/or heavy metal cations as continuation of our ongoing research [2].

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Interdisciplinarne prirodne znanosti

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