Naslov
The expression of insulin-like growth factor 2 (IGF2) in patients with oral lichen planus and diabetes mellitus

Autori
Lončar Brzak, Božana ; Sabol, Ivan ; Veliki-Dalić, Irena ; Krušlin, Božo ; Mravak-Stipetić, Marinka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts of the 14th Biennial Congress of the European Association of Oral Medicine in conjunction with the World Workshop on Oral Medicine VII / Carrozzo, Marco - Gothenburg, 2018, 77-78

Skup
14th Biennial Congress. of the European Association of Oral Medicine (EAOM 2018)

Mjesto i datum
Göteborg, Švedska, 27.09.2018. - 29.09.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
IGF2 ; OLP ; diabetes

Sažetak
Introduction: Insulin-like growth factor 2 (IGF2) has growth promoting and proliferating effect on different cell types. Increased risk of cancer development was observed in patients with type 2 diabetes mellitus, while oral lichen planus is known as premalignant lesion. Objectives: The aim of this study was to examine the expression of IGF2 in patients with oral lichen planus(OLP) and type 2 diabetes mellitus (DM). Material and methods: IGF2 expression was evaluated in paraffin-imbedded biopsy samples of oral mucosa of total of 8 patients with oral lichen planus and diabetes mellitus (OLP+DM) and 8 patients with oral lichen planus without diabetes mellitus (OLP), by comparative semiquantitative immunohistochemistry. IGF2 expression was interpreted according to the literature. A score of 0–5 was considered negative (low expression of IGF2), and a score of 6 was considered positive (high expression of IGF2). Results and conclusions: All biopsy samples in both groups of patients had negative score of IGF2 expression. Biopsy samples of OLP+DM patients had lower scores of IGF2 expression when compared to OLP group, and the difference was statistically significant (Mann-Whitney test for independent samples ; P = 0, 0014). Immunohistochemical analysis of IGF2 expression has determined variable immunoreactivity with a significant difference in final scores of IGF2 staining in biopsy samples of patients with oral lichen planus with and without diabetes mellitus, although all results were considered negative. This was a pilot study with small number of patients and further investigation on larger group of samples is required.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti, Temeljne medicinske znanosti, Dentalna medicina

Napomena
Knjiga programa i svi sažetci dostupni su na
http://eaom2018.se/programme/scientific-programme/

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