Naslov
The variation of CYP2C19 gene in the Roma population from Croatia

Autori
Zajc Petranović, Matea ; Tomas, Željka ; Škarić-Jurić, Tatjana ; Smolej Narančić, Nina ; Janićijević, Branka ; Peričić Salihović, Marijana

Izvornik
Molecular and experimental biology in medicine (2584-671X) 1 (2018), 2; 32-37

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
ADME ; CYP2C19 ; rs12248560 ; pharmacogenetics ; population isolate ; Roma (Gypsy) ; Croatia

Sažetak
CYP2C19 gene is a member of cytochrome P450 family that codes for enzyme involved in the biotransformation of 10% of commonly prescribed drugs. Inter-individual variability in CYP2C19- mediated drug metabolism is mostly due to CYP2C19 variations. This study analyses the pharmacogenetic profile of CYP2C19 in three groups of Croatian Roma (440 individuals). Ten CYP2C19 loci were genotyped, seven of which were monomorphic (rs28399504, rs4986893, rs55640102, rs56337013, rs72552267, rs72558186 and rs41291556). Minor allele frequency (MAF) of rs3758581 (defining wild-type allele, CYP2C19*1) was 56.6% in Roma, MAF of rs4244285 (CYP2C19*2) was 15.1% and of rs12248560 (CYP2C19*17) 28.3%. Frequency of the same MAFs in the surrounding majority Croatian population is 61.5%, 14.8% and 23.7%, respectively (Ganoci et al 2017). The more rapid metabolism (vs. wild type) of CYP2C19-targeted drugs is expected in 40% of the Roma (and in as much as 53.1% in the Baranja group). This is a consequence of a high prevalence (33%) of the “rapid metabolizers” (corresponding to *1/*17 genotype) and 7% of “ultrarapid metabolizers” (*17/*17) in the Croatian Roma. The results indicate that genetic profile of CYP2C19 should be taken into account in modulating pharmacotherapy in Roma population.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Javno zdravstvo i zdravstvena zaštita, Etnologija i antropologija

POVEZANOST RADA